| Literature DB >> 18947184 |
Peter J Alaimo1, Robert O'Brien, Adam W Johnson, Sarah R Slauson, Jeannette M O'Brien, Elizabeth L Tyson, Amanda-Lynn Marshall, Colleen E Ottinger, Jon G Chacon, Lorien Wallace, Corey Y Paulino, Sarah Connell.
Abstract
Domino reactions were designed to allow the byproduct of an upstream reaction to be internally recycled to catalyze a downstream reaction in a one-pot tandem sequence. Nitroarene reduction by In(0) generates an amine and In (III) byproducts. Addition of aldehyde followed by Danishefsky's diene or silyl ketene acetal provides access to dihydropyridin-4-ones or beta-amino esters, respectively, in yields that are comparable or superior to the reported stepwise reactions.Entities:
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Year: 2008 PMID： 18947184 DOI： 10.1021/ol801911f
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005