AIM: To analyze the relationship between periventricular (PV) and subcortical (SC) white matter lesions (WML) and cognitive function in patients with memory impairment. METHODS: In total, 253 patients with Global Deterioration Scale scores >or=3 who had been referred to a university-based memory unit due to memory complaints were included (mean age 69.7 years, 124 females). Cognitive function was assessed with the Mini-Mental State Examination (MMSE) and the Neurobehavioral Cognitive Status Examination (Cognistat), and full test results were available for 217 patients. PV and SC WML loads (semi-quantitative rating on axial T(2)-weighted MRI scans) were used in linear regression as predictors of cognition. RESULTS: MMSE was significantly correlated with SC WML (p = 0.005), but not with PV WML (p = 0.19). Cognistat tests for orientation, comprehension, visuoconstruction, calculation, similarities, and judgment were negatively correlated with SC WML (p < 0.01), as was verbal memory with parieto-occipital SC WML (p < 0.05). Visuoconstruction and calculation were negatively correlated with PV WML (p < 0.05). Parieto-occipital WML were more strongly related to cognition than fronto-temporal WML. Only SC WML were significantly correlated with cognition when PV and SC WML were entered simultaneously in the regression model. CONCLUSION: In patients with cognitive impairment, SC WML, in particular in parieto-occipital regions, were associated with reduced cognitive function. Copyright 2008 S. Karger AG, Basel.
AIM: To analyze the relationship between periventricular (PV) and subcortical (SC) white matter lesions (WML) and cognitive function in patients with memory impairment. METHODS: In total, 253 patients with Global Deterioration Scale scores >or=3 who had been referred to a university-based memory unit due to memory complaints were included (mean age 69.7 years, 124 females). Cognitive function was assessed with the Mini-Mental State Examination (MMSE) and the Neurobehavioral Cognitive Status Examination (Cognistat), and full test results were available for 217 patients. PV and SC WML loads (semi-quantitative rating on axial T(2)-weighted MRI scans) were used in linear regression as predictors of cognition. RESULTS: MMSE was significantly correlated with SC WML (p = 0.005), but not with PV WML (p = 0.19). Cognistat tests for orientation, comprehension, visuoconstruction, calculation, similarities, and judgment were negatively correlated with SC WML (p < 0.01), as was verbal memory with parieto-occipital SC WML (p < 0.05). Visuoconstruction and calculation were negatively correlated with PV WML (p < 0.05). Parieto-occipital WML were more strongly related to cognition than fronto-temporal WML. Only SC WML were significantly correlated with cognition when PV and SC WML were entered simultaneously in the regression model. CONCLUSION: In patients with cognitive impairment, SC WML, in particular in parieto-occipital regions, were associated with reduced cognitive function. Copyright 2008 S. Karger AG, Basel.
Authors: Reinhold Schmidt; Anja Grazer; Christian Enzinger; Stefan Ropele; Nina Homayoon; Aga Pluta-Fuerst; Petra Schwingenschuh; Petra Katschnig; Margherita Cavalieri; Helena Schmidt; Christian Langkammer; Franz Ebner; Franz Fazekas Journal: J Neural Transm (Vienna) Date: 2011-02-22 Impact factor: 3.575
Authors: Ameneh Mashayekh; Dzung L Pham; David M Yousem; Mercedes Dizon; Peter B Barker; Doris D M Lin Journal: Neuroradiology Date: 2011-03 Impact factor: 2.804
Authors: Ricardo Bajo; Nazareth P Castellanos; Maria Eugenia López; José María Ruiz; Pedro Montejo; Mercedes Montenegro; Marcos Llanero; Pedro Gil; Raquel Yubero; Evgenia Baykova; Nuria Paul; Sara Aurtenetxe; Francisco Del Pozo; Fernando Maestu Journal: Age (Dordr) Date: 2011-04-06