| Literature DB >> 18946186 |
Mitsuro Suzuki1, Qing Ding, Shiro Muranaka, Megumi Kigure, Masaaki Kojima, Misao Terada, Noyuri Kataoka, Akiko Hagiwara, Pudcharaporn Kromkhun, Naoki Moritani, Haruo Hashimoto, Makoto Yokosuka, Fujiro Sakurai, Minoru Tanaka, Toru R Saito.
Abstract
In this study, in order to clarify the kinetics of leptin, we focused on the ratio of leptin concentrations in cerebrospinal fluid and serum in aged male rats, and examined the weight of epididymal fat, and the passage rate of leptin through the blood-brain barrier. In the lighter animals, the epididymal fat weight was low, while leptin concentrations in the serum and cerebrospinal fluid were also low. Conversely, in the heavier animals, the weight of epididymal fat and leptin concentrations in the serum and cerebrospinal fluid were higher. With regard to the ratio of leptin in the cerebrospinal fluid and serum, the passage rate of leptin through the blood-brain barrier was lower in the heavier animals than in the lighter animals.Entities:
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Year: 2008 PMID： 18946186 DOI： 10.1538/expanim.57.485
Source DB: PubMed Journal: Exp Anim ISSN： 0007-5124