Literature DB >> 18942420

[Viferon suppositories in the treatment of influenza in adults].

R Z Gatich, L V Kolobukhina, A N Vasil'ev, E I Isaeva, E I Burtseva, T G Orlova, F V Voronina, V D Kol'tsov, V V Malinovskaia.   

Abstract

One hundred and one patients at the age of 18 to 60 years suffering from influenza were observed during increased ratio of the sickness due to the influenza virus types A (H1N1 and H3N2) and B. The diagnosis of influenza was confirmed by the laboratory tests. Viferon was used in the treatment of 35 patients. The randomized double blind placebo-controlled study revealed high therapeutic efficacy ofviferon and its immunomodulating effect on the T-cells, the neutrophil phagocytic activity and the decrease of the levels of the circulating immune complexes. Viferon and arbidol decreased the fever periods and the toxicosis symptoms vs. the placebo. The therapeutic efficacies of viferon and arbidol were on the whole comparable, whereas the clinical findings and the results of the immunological tests were evident of the viferon higher therapeutic and immunomodulating efficacy. No side effects of the drugs were recorded. The tolerability was excellent. Viferon can be recommended for the treatment of influenza in adults.

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Year:  2008        PMID: 18942420

Source DB:  PubMed          Journal:  Antibiot Khimioter        ISSN: 0235-2990


  2 in total

Review 1.  Arbidol as a broad-spectrum antiviral: an update.

Authors:  Julie Blaising; Stephen J Polyak; Eve-Isabelle Pécheur
Journal:  Antiviral Res       Date:  2014-04-24       Impact factor: 5.970

2.  Modeling the Structure-Activity Relationship of Arbidol Derivatives and Other SARS-CoV-2 Fusion Inhibitors Targeting the S2 Segment of the Spike Protein.

Authors:  Matthew R Freidel; Roger S Armen
Journal:  J Chem Inf Model       Date:  2021-12-13       Impact factor: 6.162

  2 in total

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