Literature DB >> 18940246

Effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice.

Fatima Elzeinova1, Vendula Novakova, Daniela Buckiova, Alena Kubatova, Jana Peknicova.   

Abstract

The effect of a low dose of vinclozolin within the development of the reproductive tract during gestation (VIN-GD 15-22) and puberty (VIN-PND 23-44) in CD1 mice was tested. We found a decrease in the anogenital distance, prostate weight and pathology of testes in both experimental groups. Sperm counts decreased to 46% (VIN-GD) and to 81% (VIN-PND), and also the acrosomal state (evaluated by antiacrosomal antibody) decreased in both groups to 89% in comparison to the control group (100%). Sperm head abnormalities increased by approximately 18% and 13%, respectively. In this connection, the expression of some genes was changed (arosome-related gene (Acr), apoptosis related genes (p53, p21)). In conclusion, a low dose of vinclozolin affected the reproductive tract, sperm parameters and expression of selected genes in both experimental groups.

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Year:  2008        PMID： 18940246     DOI： 10.1016/j.reprotox.2008.09.007

Source DB:  PubMed          Journal:  Reprod Toxicol        ISSN： 0890-6238            Impact factor:   3.143


  11 in total

1.  Morphological alterations in the freshwater rotifer Brachionus calyciflorus Pallas 1766 (Rotifera: Monogononta) caused by vinclozolin chronic exposure.

Authors:  Jesús Alvarado-Flores; Roberto Rico-Martínez; Araceli Adabache-Ortíz; Marcelo Silva-Briano
Journal:  Ecotoxicology       Date:  2015-03-01       Impact factor: 2.823

Review 2.  The effect of environmental contaminants on testicular function.

Authors:  Premendu Prakash Mathur; Shereen Cynthia D'Cruz
Journal:  Asian J Androl       Date:  2011-06-27       Impact factor: 3.285

3.  Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome.

Authors:  Carlos Guerrero-Bosagna; Matthew Settles; Ben Lucker; Michael K Skinner
Journal:  PLoS One       Date:  2010-09-30       Impact factor: 3.240

4.  Epigenetic transgenerational inheritance of vinclozolin induced mouse adult onset disease and associated sperm epigenome biomarkers.

Authors:  Carlos Guerrero-Bosagna; Trevor R Covert; Md M Haque; Matthew Settles; Eric E Nilsson; Matthew D Anway; Michael K Skinner
Journal:  Reprod Toxicol       Date:  2012-10-02       Impact factor: 3.143

Review 5.  EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals.

Authors:  A C Gore; V A Chappell; S E Fenton; J A Flaws; A Nadal; G S Prins; J Toppari; R T Zoeller
Journal:  Endocr Rev       Date:  2015-11-06       Impact factor: 19.871

6.  Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming.

Authors:  Khursheed Iqbal; Diana A Tran; Arthur X Li; Charles Warden; Angela Y Bai; Purnima Singh; Xiwei Wu; Gerd P Pfeifer; Piroska E Szabó
Journal:  Genome Biol       Date:  2015-03-27       Impact factor: 13.583

7.  Exposure to endocrine disruptor induces transgenerational epigenetic deregulation of microRNAs in primordial germ cells.

Authors:  Miguel A Brieño-Enríquez; Jesús García-López; David B Cárdenas; Sylvain Guibert; Elouan Cleroux; Lukas Děd; Juan de Dios Hourcade; Jana Pěknicová; Michael Weber; Jesús Del Mazo
Journal:  PLoS One       Date:  2015-04-21       Impact factor: 3.240

8.  Transgenerational inheritance of susceptibility to diabetes-induced male subfertility.

Authors:  Gabriela Pavlinkova; Hasmik Margaryan; Eva Zatecka; Eliska Valaskova; Fatima Elzeinova; Alena Kubatova; Romana Bohuslavova; Jana Peknicova
Journal:  Sci Rep       Date:  2017-07-10       Impact factor: 4.379

9.  Diastereomers of the brominated flame retardant 1,2-dibromo-4-(1,2 dibromoethyl)cyclohexane induce androgen receptor activation in the hepg2 hepatocellular carcinoma cell line and the lncap prostate cancer cell line.

Authors:  Hazem Khalaf; Anders Larsson; Håkan Berg; Robert McCrindle; Gilles Arsenault; Per-Erik Olsson
Journal:  Environ Health Perspect       Date:  2009-08-03       Impact factor: 9.031

Review 10.  Similar causes of various reproductive disorders in early life.

Authors:  Konstantin Svechnikov; Jan-Bernd Stukenborg; Iuliia Savchuck; Olle Söder
Journal:  Asian J Androl       Date:  2014 Jan-Feb       Impact factor: 3.285
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