Strategies for primary prevention of atopy in children.

In recent decades, the prevalence of atopic diseases such as asthma, hayfever, food allergy, and atopic dermatitis has been steadily increasing. Unfortunately, more advances have been made in secondary prevention of symptoms and exacerbations than in primary prevention. One barrier to adopting prevention strategies is uncertainty regarding the cause of atopy. A genetic predisposition has been well documented. However, other factors, including diet, environment, infections, medications, and gastrointestinal flora, all play a role in the development of atopic disease. Modifying these factors holds promise for stopping the atopic march in the future. This paper reviews advances that have been made in the primary prevention of atopic disease.