| Literature DB >> 1894013 |
O M Avrech1, A Golan, Z Weinraub, I Bukovsky, E Caspi.
Abstract
The availability of a medical mode of termination of early pregnancy by the administration of RU486, an antiprogesterone alone, or in combination with one of the PG analogues significantly reduces the maternal morbidity and mortality associated with the classical surgical abortion. RU486 given alone in early pregnancy induces complete abortion in 60% to 85% of cases, and when combined with prostaglandin analogues, gemeprost or sulprostone, reaches a success rate of 95% to 99%. RU486 may also be of potential value in the medical treatment of ectopic pregnancy. Its use as a postcoital contraception is suggested, but further research is required to determine whether RU486 can be used on a once-a-month basis for contraception.Entities:
Keywords: Abortion, Drug Induced; Abortion, Induced; Adrenal Cortex Effects; Asia; Biology; Contraception; Contraception Research; Contraceptive Agents; Contraceptive Agents, Female; Contraceptive Agents, Postcoital; Contraceptive Mode Of Action; Demographic Factors; Developed Countries; Diseases; Endocrine Effects; Endocrine System; Endometrial Effects; Endometrium; Family Planning; Fertility Control, Postcoital; Fertility Control, Postconception; Genitalia; Genitalia, Female; Gonadotropins; Gonadotropins, Pituitary; Hormone Antagonists; Hormone Receptors; Hormones; Israel; Literature Review; Maternal Mortality; Mediterranean Countries; Membrane Proteins; Morbidity--women; Mortality; Ovulation Suppression; Physiology; Population; Population Dynamics; Pregnancy; Pregnancy Complications; Pregnancy, Ectopic; Pregnancy, First Trimester; Products Of Conception, Retention; Progestational Hormones; Progesterone; Prostaglandins; Prostaglandins, Synthetic; Reproduction; Ru-486; Urogenital System; Uterus; Western Asia
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Year: 1991 PMID： 1894013 DOI： 10.1016/s0015-0282(16)54527-0
Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329