| Literature DB >> 18938766 |
Eric Guedj1, Gilles Allali, Celine Goetz, Isabelle Le Ber, Magali Volteau, Lucette Lacomblez, Pierre Vera, Anne Hitzel, Didier Hannequin, Marielle Decousus, Catherine Thomas-Antérion, Christine Magne, Martine Vercelletto, Anne-Marie Bernard, Mira Didic, Jean-Albert Lotterie, Michèle Puel, Alexis Brice, Marie-Odile Habert, Bruno Dubois.
Abstract
The objective of this study is to identify the cerebral regions that are assessed by the Frontal Assessment Battery (FAB). Using SPM voxel-based analysis, we looked for correlations between FAB performance and brain SPECT perfusion in 47 patients with the frontal variant of frontotemporal dementia (fv-FTD) recruited by the French FTD research network, a multicentre initiative of French University hospitals with expertise in the field of dementia. A significant correlation was found between FAB performance and perfusion in the medial and dorsolateral frontal cortex bilaterally, independently of age, gender and MMSE. No correlations were observed with orbital frontal or parietal perfusion, in spite of the presence of hypoperfusion in these areas, or with perfusion of any other cortical or subcortical region. These findings confirm that the FAB is an adequate tool for assessing functions related to the dorsolateral and medial frontal cortex, and is thus useful for the evaluation of diseases associated with frontal dysfunction.Entities:
Mesh：
Year: 2008 PMID： 18938766 DOI： 10.1016/j.jns.2008.06.035
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181