V Jivan1, M Altini, S Meer. 1. Division of Oral Pathology, School of Oral Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Abstract
OBJECTIVE: To undertake a detailed histological investigation of a large series of adenomatoid odontogenic tumours (AOT) to document the frequency and histomorphology of secretory cells which might indicate an inductive capacity. MATERIALS AND METHODS: Haematoxylin and eosin stained sections of 51 cases of AOT were reviewed. Selected cases were stained with periodic acid-schiff (PAS) and Congo red. RESULTS: In five cases, secretory structures with a circular arrangement of tall columnar cells secreting enameloid-like matrix material were identified. Such structures have only very rarely been identified in AOT and their frequency, distribution and morphology have not been adequately documented. CONCLUSIONS: We have documented the presence of tall secretory columnar cells, arranged in a circular configuration actively secreting enameloid-like material and believe that such an ordered arrangement of secretory cells is more likely a result of tissue induction rather than metaplasia. The origin of these secretory structures from the pseudo-ductular component is unlikely but cannot be ruled out.
OBJECTIVE: To undertake a detailed histological investigation of a large series of adenomatoid odontogenic tumours (AOT) to document the frequency and histomorphology of secretory cells which might indicate an inductive capacity. MATERIALS AND METHODS:Haematoxylin and eosin stained sections of 51 cases of AOT were reviewed. Selected cases were stained with periodic acid-schiff (PAS) and Congo red. RESULTS: In five cases, secretory structures with a circular arrangement of tall columnar cells secreting enameloid-like matrix material were identified. Such structures have only very rarely been identified in AOT and their frequency, distribution and morphology have not been adequately documented. CONCLUSIONS: We have documented the presence of tall secretory columnar cells, arranged in a circular configuration actively secreting enameloid-like material and believe that such an ordered arrangement of secretory cells is more likely a result of tissue induction rather than metaplasia. The origin of these secretory structures from the pseudo-ductular component is unlikely but cannot be ruled out.
Authors: Felipe Rodrigues de Matos; Cassiano Francisco Weege Nonaka; Leão Pereira Pinto; Lélia Batista de Souza; Roseana de Almeida Freitas Journal: Head Neck Pathol Date: 2012-08-07