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Literature DB >> 18936755

One SNP linked to two diseases-addiction and cancer: a double whammy? Nicotine addiction and lung cancer susceptibility.

N Volkow¹, J Rutter, J D Pollock, D Shurtleff, R Baler.

Abstract

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18936755 PMCID： PMC4827504 DOI： 10.1038/mp.2008.71

Source DB: PubMed Journal: Mol Psychiatry ISSN： 1359-4184 Impact factor: 15.992

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15 in total

1. Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster.

Authors: J Boulter; A O'Shea-Greenfield; R M Duvoisin; J G Connolly; E Wada; A Jensen; P D Gardner; M Ballivet; E S Deneris; D McKinnon
Journal: J Biol Chem Date: 1990-03-15 Impact factor: 5.157

2. The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines on BEP2D cells.

Authors: Juan Arredondo; Alex I Chernyavsky; Sergei A Grando
Journal: J Cancer Res Clin Oncol Date: 2006-07-12 Impact factor: 4.553

3. Thoughts about the cause of cancer.

Authors: Steven I Hajdu
Journal: Cancer Date: 2006-04-15 Impact factor: 6.860

4. In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs.

Authors: Giulia Soldà; Silvia Boi; Stefano Duga; Diego Fornasari; Roberta Benfante; Massimo Malcovati; Maria Luisa Tenchini
Journal: Gene Date: 2005-01-05 Impact factor: 3.688

5. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.

Authors: Christopher I Amos; Xifeng Wu; Peter Broderick; Ivan P Gorlov; Jian Gu; Timothy Eisen; Qiong Dong; Qing Zhang; Xiangjun Gu; Jayaram Vijayakrishnan; Kate Sullivan; Athena Matakidou; Yufei Wang; Gordon Mills; Kimberly Doheny; Ya-Yu Tsai; Wei Vivien Chen; Sanjay Shete; Margaret R Spitz; Richard S Houlston
Journal: Nat Genet Date: 2008-04-02 Impact factor: 38.330

6. Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells.

Authors: S Zia; A Ndoye; V T Nguyen; S A Grando
Journal: Res Commun Mol Pathol Pharmacol Date: 1997-09

Review 7. The genetic epidemiology of smoking.

Authors: P F Sullivan; K S Kendler
Journal: Nicotine Tob Res Date: 1999 Impact factor: 4.244

8. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.

Authors: Rayjean J Hung; James D McKay; Valerie Gaborieau; Paolo Boffetta; Mia Hashibe; David Zaridze; Anush Mukeria; Neonilia Szeszenia-Dabrowska; Jolanta Lissowska; Peter Rudnai; Eleonora Fabianova; Dana Mates; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Chu Chen; Gary Goodman; John K Field; Triantafillos Liloglou; George Xinarianos; Adrian Cassidy; John McLaughlin; Geoffrey Liu; Steven Narod; Hans E Krokan; Frank Skorpen; Maiken Bratt Elvestad; Kristian Hveem; Lars Vatten; Jakob Linseisen; Françoise Clavel-Chapelon; Paolo Vineis; H Bas Bueno-de-Mesquita; Eiliv Lund; Carmen Martinez; Sheila Bingham; Torgny Rasmuson; Pierre Hainaut; Elio Riboli; Wolfgang Ahrens; Simone Benhamou; Pagona Lagiou; Dimitrios Trichopoulos; Ivana Holcátová; Franco Merletti; Kristina Kjaerheim; Antonio Agudo; Gary Macfarlane; Renato Talamini; Lorenzo Simonato; Ray Lowry; David I Conway; Ariana Znaor; Claire Healy; Diana Zelenika; Anne Boland; Marc Delepine; Mario Foglio; Doris Lechner; Fumihiko Matsuda; Helene Blanche; Ivo Gut; Simon Heath; Mark Lathrop; Paul Brennan
Journal: Nature Date: 2008-04-03 Impact factor: 49.962

9. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.

Authors: Thorgeir E Thorgeirsson; Frank Geller; Patrick Sulem; Thorunn Rafnar; Anna Wiste; Kristinn P Magnusson; Andrei Manolescu; Gudmar Thorleifsson; Hreinn Stefansson; Andres Ingason; Simon N Stacey; Jon T Bergthorsson; Steinunn Thorlacius; Julius Gudmundsson; Thorlakur Jonsson; Margret Jakobsdottir; Jona Saemundsdottir; Olof Olafsdottir; Larus J Gudmundsson; Gyda Bjornsdottir; Kristleifur Kristjansson; Halla Skuladottir; Helgi J Isaksson; Tomas Gudbjartsson; Gregory T Jones; Thomas Mueller; Anders Gottsäter; Andrea Flex; Katja K H Aben; Femmie de Vegt; Peter F A Mulders; Dolores Isla; Maria J Vidal; Laura Asin; Berta Saez; Laura Murillo; Thorsteinn Blondal; Halldor Kolbeinsson; Jon G Stefansson; Ingunn Hansdottir; Valgerdur Runarsdottir; Roberto Pola; Bengt Lindblad; Andre M van Rij; Benjamin Dieplinger; Meinhard Haltmayer; Jose I Mayordomo; Lambertus A Kiemeney; Stefan E Matthiasson; Hogni Oskarsson; Thorarinn Tyrfingsson; Daniel F Gudbjartsson; Jeffrey R Gulcher; Steinn Jonsson; Unnur Thorsteinsdottir; Augustine Kong; Kari Stefansson
Journal: Nature Date: 2008-04-03 Impact factor: 49.962

One SNP linked to two diseases-addiction and cancer: a double whammy? Nicotine addiction and lung cancer susceptibility.

1. Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster.

2. The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines on BEP2D cells.

3. Thoughts about the cause of cancer.

4. In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs.

5. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.

6. Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells.

Review 7. The genetic epidemiology of smoking.

8. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.

9. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.

10. The nicotinic acetylcholine receptor subunit alpha 5 mediates short-term effects of nicotine in vivo.

Review 1. Addiction as a systems failure: focus on adolescence and smoking.

2. Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors.

Review 3. Transcriptional and epigenetic mechanisms of addiction.

Review 4. The genetics of substance dependence.

5. Re-defininG AddiC(CH3)Tion: genomics and epigenomics on substance use disorders.

6. Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence.