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14 in total

1. On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition.

Authors: Weimin Mao; Mark S Warren; Deborah S Black; Takahumi Satou; Takeshi Murata; Takeshi Nishino; Naomasa Gotoh; Olga Lomovskaya
Journal: Mol Microbiol Date: 2002-11 Impact factor: 3.501

2. Mutations in the central cavity and periplasmic domain affect efflux activity of the resistance-nodulation-division pump EmhB from Pseudomonas fluorescens cLP6a.

Authors: Elizabeth M Hearn; Murray R Gray; Julia M Foght
Journal: J Bacteriol Date: 2006-01 Impact factor: 3.490

Review 3. Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria.

Authors: Laura J V Piddock
Journal: Clin Microbiol Rev Date: 2006-04 Impact factor: 26.132

4. Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism.

Authors: Markus A Seeger; André Schiefner; Thomas Eicher; François Verrey; Kay Diederichs; Klaas M Pos
Journal: Science Date: 2006-09-01 Impact factor: 47.728

Review 5. Antibiotic resistance caused by gram-negative multidrug efflux pumps.

Authors: H Nikaido
Journal: Clin Infect Dis Date: 1998-08 Impact factor: 9.079

6. Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants Selected with a fluoroquinolone.

Authors: A S Jellen-Ritter; W V Kern
Journal: Antimicrob Agents Chemother Date: 2001-05 Impact factor: 5.191

7. Chimeric analysis of the multicomponent multidrug efflux transporters from gram-negative bacteria.

Authors: Elena B Tikhonova; Quiju Wang; Helen I Zgurskaya
Journal: J Bacteriol Date: 2002-12 Impact factor: 3.490

8. Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops.

Authors: Christopher A Elkins; Hiroshi Nikaido
Journal: J Bacteriol Date: 2002-12 Impact factor: 3.490

9. A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study.

Authors: Edward W Yu; Julio R Aires; Gerry McDermott; Hiroshi Nikaido
Journal: J Bacteriol Date: 2005-10 Impact factor: 3.490

10. Differential impact of MexB mutations on substrate selectivity of the MexAB-OprM multidrug efflux pump of Pseudomonas aeruginosa.

Authors: Jocelyn K Middlemiss; Keith Poole
Journal: J Bacteriol Date: 2004-03 Impact factor: 3.490

26 in total

1. Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.

Authors: Thomas Eicher; Hi-jea Cha; Markus A Seeger; Lorenz Brandstätter; Jasmin El-Delik; Jürgen A Bohnert; Winfried V Kern; François Verrey; Markus G Grütter; Kay Diederichs; Klaas M Pos
Journal: Proc Natl Acad Sci U S A Date: 2012-03-26 Impact factor: 11.205

Review 2. Efflux-mediated drug resistance in bacteria: an update.

Authors: Xian-Zhi Li; Hiroshi Nikaido
Journal: Drugs Date: 2009-08-20 Impact factor: 9.546

3. Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli.

Authors: Yumiko Takatsuka; Cheng Chen; Hiroshi Nikaido
Journal: Proc Natl Acad Sci U S A Date: 2010-03-08 Impact factor: 11.205

Review 4. The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Authors: Xian-Zhi Li; Patrick Plésiat; Hiroshi Nikaido
Journal: Clin Microbiol Rev Date: 2015-04 Impact factor: 26.132

5. Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors.

Authors: Attilio V Vargiu; Paolo Ruggerone; Timothy J Opperman; Son T Nguyen; Hiroshi Nikaido
Journal: Antimicrob Agents Chemother Date: 2014-08-11 Impact factor: 5.191

6. Switch-loop flexibility affects transport of large drugs by the promiscuous AcrB multidrug efflux transporter.

Authors: Hi-jea Cha; Reinke T Müller; Klaas M Pos
Journal: Antimicrob Agents Chemother Date: 2014-06-09 Impact factor: 5.191

7. Evidence of a Substrate-Discriminating Entrance Channel in the Lower Porter Domain of the Multidrug Resistance Efflux Pump AcrB.

Authors: Sabine Schuster; Martina Vavra; Winfried V Kern
Journal: Antimicrob Agents Chemother Date: 2016-06-20 Impact factor: 5.191

8. Efflux-Mediated Resistance to New Oxazolidinones and Pleuromutilin Derivatives in Escherichia coli with Class Specificities in the Resistance-Nodulation-Cell Division-Type Drug Transport Pathways.

Authors: Sabine Schuster; Martina Vavra; Winfried V Kern
Journal: Antimicrob Agents Chemother Date: 2019-08-23 Impact factor: 5.191

Review 9. Natural Products as Platforms To Overcome Antibiotic Resistance.

Authors: Sean E Rossiter; Madison H Fletcher; William M Wuest
Journal: Chem Rev Date: 2017-09-27 Impact factor: 60.622

10. New Topoisomerase Inhibitors: Evaluating the Potency of Gepotidacin and Zoliflodacin in Fluoroquinolone-Resistant Escherichia coli upon tolC Inactivation and Differentiating Their Efflux Pump Substrate Nature.

Authors: Sabine Schuster; Martina Vavra; Raphael Köser; John W A Rossen; Winfried V Kern
Journal: Antimicrob Agents Chemother Date: 2021-01-20 Impact factor: 5.191