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Literature DB >> 1893488

A cytotoxic substance from Sangre de Grado.

H Itokawa¹, Y Ichihara, M Mochizuki, T Enomori, H Morita, O Shirota, M Inamatsu, K Takeya.

Abstract

Taspine has been isolated as a cytotoxic substance from Sangre de Grado, sap of Croton palanostigma (Euphorbiaceae), by bioassay guided fractionation. The cytotoxicity (IC50) of taspine was found to be 0.39 microgram/ml against KB cells and 0.17 microgram/ml against V-79 cells.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1991 PMID： 1893488 DOI： 10.1248/cpb.39.1041

Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645

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Cited

7 in total

1. Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis.

Authors: Maria Berndtsson; Emma Hernlund; Maria C Shoshan; Stig Linder
Journal: J Chem Biol Date: 2009-03-31

2. A novel biphenyl urea derivate inhibits the invasion of breast cancer through the modulation of CXCR4.

Authors: Yingzhuan Zhan; Han Zhang; Jing Li; Yanmin Zhang; Jie Zhang; Langchong He
Journal: J Cell Mol Med Date: 2015-03-08 Impact factor: 5.310

3. Croton Tiglium Extract Induces Apoptosis via Bax/Bcl-2 Pathways in Human Lung Cancer A549 Cells

Authors: Changyou Li; Xiao Wu; Rongli Sun; Peng Zhao; Fengjuan Liu; Chunling Zhang
Journal: Asian Pac J Cancer Prev Date: 2016-11-01

4. Antitumor Effect of the Essential Oil from the Leaves of Croton matourensis Aubl. (Euphorbiaceae).

Authors: Emilly J S P de Lima; Rafaela G Alves; Gigliola M A D Elia; Talita A da Anunciação; Valdenizia R Silva; Luciano de S Santos; Milena B P Soares; Nállarett M D Cardozo; Emmanoel V Costa; Felipe M A da Silva; Hector H F Koolen; Daniel P Bezerra
Journal: Molecules Date: 2018-11-14 Impact factor: 4.411

A cytotoxic substance from Sangre de Grado.

1. Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis.

2. A novel biphenyl urea derivate inhibits the invasion of breast cancer through the modulation of CXCR4.

3. Croton Tiglium Extract Induces Apoptosis via Bax/Bcl-2 Pathways in Human Lung Cancer A549 Cells

4. Antitumor Effect of the Essential Oil from the Leaves of Croton matourensis Aubl. (Euphorbiaceae).

5. Hypoxia Stimulates SUMOylation-Dependent Stabilization of KDM5B.

6. Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters.

Review 7. Genus caulophyllum: an overview of chemistry and bioactivity.