Literature DB >> 1893295

Hydrochlorothiazide inhibits parathormone-stimulated increase in plasma tartrate-resistant acid phosphatase in mice.

P D Broulik1, V Pacovský.   

Abstract

The inhibitory effect of hydrochlorothiazide (HTZ) on parathormone-induced bone changes in mice was studied with the aid of the analysis of plasma calcium and tartrate-resistant acid phosphatase. We have found that HTZ alone had no effect on plasma tartrate-resistant acid phosphatase (Tr-ACP), phosphate, and creatinine concentration. Parathormone (PTH) administration increased plasma Tr-ACP from 15.00 +/- 1.50 to 20.62 +/- 2.35 U/liter in intact mice. The increase of plasma Tr-ACP in HTZ-treated mice after PTH administration was not significant. The plasma calcium was affected in a way similar to Tr-ACP. HTZ reduced the sensitivity of bone to resorbing effects of PTH, using Tr-ACP as a useful biomarker of bone resorption.

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Year:  1991        PMID： 1893295     DOI： 10.1007/bf02555902

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  12 in total

1.  Endogenous creatinine in serum and urine.

Authors:  R S HARE
Journal:  Proc Soc Exp Biol Med       Date:  1950-05

2.  Effect of parathyroid extract on blood calcium and osteoclast count in mice.

Authors:  A Tatevossian
Journal:  Calcif Tissue Res       Date:  1973-03-12

3.  The effect of parathyroid extract on cellular activity and plasma calcium levels in vivo.

Authors:  P J Bingham; I A Brazell; M Owen
Journal:  J Endocrinol       Date:  1969-11       Impact factor: 4.286

4.  Thiazide-induced parathyroid stimulation.

Authors:  J R Pickleman; F H Straus; M Forland; E Paloyan
Journal:  Metabolism       Date:  1969-10       Impact factor: 8.694

5.  Relationship of plasma tartrate resistant acid phosphatase to the bone isoenzyme of serum alkaline phosphatase in hyperparathyroidism.

Authors:  J J Stĕpan; E Silinková-Málková; T Havránek; J Formánková; M Zichová; J Lachmanová; M Straková; P Broulik; V Pacovský
Journal:  Clin Chim Acta       Date:  1983-09-30       Impact factor: 3.786

Review 6.  Skeletal actions of parathyroid hormone.

Authors:  G Wong
Journal:  Miner Electrolyte Metab       Date:  1982 Sep-Oct

7.  Calcium and sodium transport by the distal convoluted tubule of the rat.

Authors:  L S Costanzo; E E Windhager
Journal:  Am J Physiol       Date:  1978-11

8.  changes in serum and urinary calcium during treatment with hydrochlorothiazide: studies on mechanisms.

Authors:  A S Brickman; S G Massry; J W Coburn
Journal:  J Clin Invest       Date:  1972-04       Impact factor: 14.808

9.  Thiazide effect on the mineral content of bone.

Authors:  R D Wasnich; R J Benfante; K Yano; L Heilbrun; J M Vogel
Journal:  N Engl J Med       Date:  1983-08-11       Impact factor: 91.245

10.  Effects of chlorothiazide on 1,25-dihydroxyvitamin D3, parathyroid hormone, and intestinal calcium absorption in the rat.

Authors:  M J Favus; F L Coe; S C Kathpalia; A Porat; P K Sen; L M Sherwood
Journal:  Am J Physiol       Date:  1982-06
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  3 in total

1.  Effects of continuous glucocorticoid infusion on bone metabolism in the rat.

Authors:  C S King; E C Weir; C W Gundberg; J Fox; K L Insogna
Journal:  Calcif Tissue Int       Date:  1996-09       Impact factor: 4.333

2.  Mitogenic action of hydrochlorothiazide on human osteoblasts in vitro: requirement for platelet-derived growth factor.

Authors:  K H Lau; X D Song; M Ochi; J E Wergedal
Journal:  Calcif Tissue Int       Date:  1996-12       Impact factor: 4.333

Review 3.  Nephrolithiasis-associated bone disease: pathogenesis and treatment options.

Authors:  Khashayar Sakhaee; Naim M Maalouf; Rajiv Kumar; Andreas Pasch; Orson W Moe
Journal:  Kidney Int       Date:  2010-12-01       Impact factor: 10.612
  3 in total

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