BACKGROUND: Atrial fibrillation (AF) and atrial flutter (AFL) are common cardiac conduction disorders affecting many people. Recent studies on sporadic cases of AF/AFL showed a significant association of the single nucleotide polymorphism rs2200733T with the disease, suggesting a genetic factor in the development of the disease. OBJECTIVES: To determine the association of rs2200733 with AF/AFL derived from an Italian population sample. SUBJECTS: 78 patients with AF/AFL and 348 controls took part in the study. DESIGN: Genetic case-control study. RESULTS: The results indicate that there is a positive, significant association between the rs2200733 T allele and patients with AF/AFL of Italian origin (allelic p<0.001 with OR = 2.17). CONCLUSION: These results derived from a sample of the Italian population agree with previously reported findings from an Icelandic study, which also found that the minor allele rs2200733 was associated with AF/AFL disease.
BACKGROUND:Atrial fibrillation (AF) and atrial flutter (AFL) are common cardiac conduction disorders affecting many people. Recent studies on sporadic cases of AF/AFL showed a significant association of the single nucleotide polymorphism rs2200733T with the disease, suggesting a genetic factor in the development of the disease. OBJECTIVES: To determine the association of rs2200733 with AF/AFL derived from an Italian population sample. SUBJECTS: 78 patients with AF/AFL and 348 controls took part in the study. DESIGN: Genetic case-control study. RESULTS: The results indicate that there is a positive, significant association between the rs2200733 T allele and patients with AF/AFL of Italian origin (allelic p<0.001 with OR = 2.17). CONCLUSION: These results derived from a sample of the Italian population agree with previously reported findings from an Icelandic study, which also found that the minor allele rs2200733 was associated with AF/AFL disease.
Authors: Steven A Lubitz; Moritz F Sinner; Kathryn L Lunetta; Seiko Makino; Arne Pfeufer; Rosanna Rahman; Caroline E Veltman; John Barnard; Joshua C Bis; Stephan P Danik; Akshata Sonni; Marisa A Shea; Federica Del Monte; Siegfried Perz; Martina Müller; Annette Peters; Steven M Greenberg; Karen L Furie; Charlotte van Noord; Eric Boerwinkle; Bruno H C Stricker; Jacqueline Witteman; Jonathan D Smith; Mina K Chung; Susan R Heckbert; Emelia J Benjamin; Jonathan Rosand; Dan E Arking; Alvaro Alonso; Stefan Kääb; Patrick T Ellinor Journal: Circulation Date: 2010-08-23 Impact factor: 29.690
Authors: Jason D Roberts; Jonathan C Hsu; Bradley E Aouizerat; Clive R Pullinger; Mary J Malloy; John P Kane; Jeffrey E Olgin; Gregory M Marcus Journal: J Cardiovasc Electrophysiol Date: 2013-12-13