Literature DB >> 18931113

Dissecting the role of the N-terminal region of the Escherichia coli global transcription factor FNR.

Aixin Yan1, Patricia J Kiley.   

Abstract

The role of the N-terminal region of the transcription factor FNR, which immediately precedes the first ligand (Cys20) of the [4Fe-4S] cluster, was investigated. We found that truncation mutants that removed residues 2 to 16 and 2 to 17 had wild-type levels of FNR protein but surprisingly altered O(2) regulation.

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Year:  2008        PMID： 18931113      PMCID： PMC2593217          DOI： 10.1128/JB.01242-08

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  19 in total

Review 1.  Phylogeny of the bacterial superfamily of Crp-Fnr transcription regulators: exploiting the metabolic spectrum by controlling alternative gene programs.

Authors:  Heinz Körner; Heidi J Sofia; Walter G Zumft
Journal:  FEMS Microbiol Rev       Date:  2003-12       Impact factor: 16.408

2.  Fnr mutants that activate gene expression in the presence of oxygen.

Authors:  P J Kiley; W S Reznikoff
Journal:  J Bacteriol       Date:  1991-01       Impact factor: 3.490

3.  In vivo and in vitro mutants of FNR the anaerobic transcriptional regulator of E. coli.

Authors:  A D Sharrocks; J Green; J R Guest
Journal:  FEBS Lett       Date:  1990-09-17       Impact factor: 4.124

4.  Mutations in fnr that alter anaerobic regulation of electron transport-associated genes in Escherichia coli.

Authors:  S B Melville; R P Gunsalus
Journal:  J Biol Chem       Date:  1990-11-05       Impact factor: 5.157

5.  Characterization of FNR* mutant proteins indicates two distinct mechanisms for altering oxygen regulation of the Escherichia coli transcription factor FNR.

Authors:  D M Bates; B A Lazazzera; P J Kiley
Journal:  J Bacteriol       Date:  1995-07       Impact factor: 3.490

6.  The activity of the Escherichia coli transcription factor FNR is regulated by a change in oligomeric state.

Authors:  B A Lazazzera; D M Bates; P J Kiley
Journal:  Genes Dev       Date:  1993-10       Impact factor: 11.361

7.  Substitution of leucine 28 with histidine in the Escherichia coli transcription factor FNR results in increased stability of the [4Fe-4S](2+) cluster to oxygen.

Authors:  D M Bates; C V Popescu; N Khoroshilova; K Vogt; H Beinert; E Münck; P J Kiley
Journal:  J Biol Chem       Date:  2000-03-03       Impact factor: 5.157

8.  Association of a polynuclear iron-sulfur center with a mutant FNR protein enhances DNA binding.

Authors:  N Khoroshilova; H Beinert; P J Kiley
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205

9.  DNA binding and dimerization of the Fe-S-containing FNR protein from Escherichia coli are regulated by oxygen.

Authors:  B A Lazazzera; H Beinert; N Khoroshilova; M C Kennedy; P J Kiley
Journal:  J Biol Chem       Date:  1996-02-02       Impact factor: 5.157

10.  Transcription factor distribution in Escherichia coli: studies with FNR protein.

Authors:  David C Grainger; Hirofumi Aiba; Douglas Hurd; Douglas F Browning; Stephen J W Busby
Journal:  Nucleic Acids Res       Date:  2006-12-12       Impact factor: 16.971
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  3 in total

Review 1.  Reassessing the Structure and Function Relationship of the O2 Sensing Transcription Factor FNR.

Authors:  Erin L Mettert; Patricia J Kiley
Journal:  Antioxid Redox Signal       Date:  2017-11-14       Impact factor: 8.401

2.  Modulation of gene expression in Actinobacillus pleuropneumoniae exposed to bronchoalveolar fluid.

Authors:  Abdul G Lone; Vincent Deslandes; John H E Nash; Mario Jacques; Janet I Macinnes
Journal:  PLoS One       Date:  2009-07-03       Impact factor: 3.240

3.  Identification and Unusual Properties of the Master Regulator FNR in the Extreme Acidophile Acidithiobacillus ferrooxidans.

Authors:  Héctor Osorio; Erin Mettert; Patricia Kiley; Mark Dopson; Eugenia Jedlicki; David S Holmes
Journal:  Front Microbiol       Date:  2019-07-19       Impact factor: 5.640
  3 in total

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