Systemic adverse drug reactions: a preliminary report from the regional pharmacovigilance center, western Nepal.

Present study analyzed the pattern, causality, severity and preventability of the systemic adverse drug reactions reported to the regional pharmacovigilance center during the period 14th September 2004 till 13th September 2005. Altogether the centre received 22 systemic adverse drug reactions [males 12 (54.55%), females 10 (45.45%)]. Among the total adverse drug reaction 5 (22.73%) were reported by the Department of Orthopedics. Of the 22 drugs responsible for the suspected adverse drug reaction, majority belongs to the class of opioid analgesics [n=7, (31.82%)], followed by non steroidal anti-inflammatory drugs [n=5, (22.73%)]. Tramadol was the individual drug responsible for 6 (27.27%) adverse drug reactions and vomiting was the most common adverse drug reactions [n=6, (27.27%)]. The causality assessment revealed 7 (31.82%) of the adverse drug reaction to have a probable relationship with the suspected drugs.