PURPOSE: To test, in a prospective Phase I/II trial, a partial breast irradiation technique using a 103Pd permanent breast seed implant (PBSI) realized in a single 1-h procedure under sedation and local freezing. METHODS AND MATERIALS: Eligible patients had infiltrating ductal carcinoma < or = 3 cm in diameter, surgical margin > or = 2 mm, no extensive intraductal component, no lymphovascular invasion, and negative lymph nodes. Patients received a permanent seed implant, and a minimal peripheral dose of 90 Gy was prescribed to the clinical target volume, with a margin of 1.5 cm. RESULTS: From May 2004 to April 2007, 67 patients received the PBSI treatment. The procedure was well tolerated, with 17% of patients having significant pain after the procedure. Only 1 patient (1.5%) had an acute skin reaction (Grade 3 according to the National Cancer Institute Common Toxicity Criteria). The rates of acute moist desquamation, erythema, and indurations were 10.4%, 42%, and 27%, respectively. At 1 year the rate of Grade 1 telangiectasia was 14%. The rate of skin reaction decreased from 65% to 28% when skin received less than the 85% isodose. According to a Radiation Therapy Oncology Group questionnaire, 80-90% of patients were very satisfied with their treatment, and the remainder were satisfied. One patient (1.5%) developed an abscess, which resolved after the use of antibiotics. There was no recurrence after a median follow-up of 32 months (range, 11-49 months). CONCLUSIONS: The feasibility, safety, and tolerability of PBSI compares favorably with that of external beam and other partial breast irradiation techniques.
PURPOSE: To test, in a prospective Phase I/II trial, a partial breast irradiation technique using a 103Pd permanent breast seed implant (PBSI) realized in a single 1-h procedure under sedation and local freezing. METHODS AND MATERIALS: Eligible patients had infiltrating ductal carcinoma < or = 3 cm in diameter, surgical margin > or = 2 mm, no extensive intraductal component, no lymphovascular invasion, and negative lymph nodes. Patients received a permanent seed implant, and a minimal peripheral dose of 90 Gy was prescribed to the clinical target volume, with a margin of 1.5 cm. RESULTS: From May 2004 to April 2007, 67 patients received the PBSI treatment. The procedure was well tolerated, with 17% of patients having significant pain after the procedure. Only 1 patient (1.5%) had an acute skin reaction (Grade 3 according to the National Cancer Institute Common Toxicity Criteria). The rates of acute moist desquamation, erythema, and indurations were 10.4%, 42%, and 27%, respectively. At 1 year the rate of Grade 1 telangiectasia was 14%. The rate of skin reaction decreased from 65% to 28% when skin received less than the 85% isodose. According to a Radiation Therapy Oncology Group questionnaire, 80-90% of patients were very satisfied with their treatment, and the remainder were satisfied. One patient (1.5%) developed an abscess, which resolved after the use of antibiotics. There was no recurrence after a median follow-up of 32 months (range, 11-49 months). CONCLUSIONS: The feasibility, safety, and tolerability of PBSI compares favorably with that of external beam and other partial breast irradiation techniques.
Authors: Xiaochun Wang; Richard A Amos; Xiaodong Zhang; Phillip J Taddei; Wendy A Woodward; Karen E Hoffman; Tse Kuan Yu; Welela Tereffe; Julia Oh; George H Perkins; Mohammad Salehpour; Sean X Zhang; Tzou Liang Sun; Michael Gillin; Thomas A Buchholz; Eric A Strom Journal: Int J Radiat Oncol Biol Phys Date: 2010-08-12 Impact factor: 7.038
Authors: Katija Bonin; Merrylee McGuffin; Roseanna Presutti; Tamara Harth; Aruz Mesci; Deb Feldman-Stewart; Edward Chow; Lisa Di Prospero; Danny Vesprini; Eileen Rakovitch; Justin Lee; Lawrence Paszat; Mary Doherty; Hany Soliman; Ida Ackerman; Xingshan Cao; Alex Kiss; Ewa Szumacher Journal: J Cancer Educ Date: 2018-02 Impact factor: 2.037
Authors: Muhammad Hammad Aziz; Frank Schneider; Sven Clausen; Elena Blank; Carsten Herskind; Muhammad Afzal; Frederik Wenz Journal: Radiat Oncol Date: 2011-12-16 Impact factor: 3.481