Literature DB >> 18930324

Regulation of calcium-sensing-receptor trafficking and cell-surface expression by GPCRs and RAMPs.

Tristan Bouschet1, Stéphane Martin, Jeremy M Henley.   

Abstract

The calcium-sensing (CaS) receptor is a G-protein-coupled receptor (GPCR) that is of fundamental importance for extracellular calcium signalling and calcium homeostasis. The CaS receptor detects changes in free, ionized extracellular calcium concentration and initiates pathways that constantly re-adjust levels of circulating calcium. In addition, the CaS receptor is involved in processes such as stem-cell homing and regulation of neuronal-process outgrowth. To perform these functions, the CaS receptor must be appropriately targeted to the plasma membrane so that its large N-terminal calcium-sensing domain is positioned in the extracellular environment to detect dynamic changes in ionic calcium concentration. Here, we provide an overview of the molecular determinants controlling CaS receptor forward traffic and highlight the roles of CaS receptor interactors such as receptor-activity-modifying proteins and subunits of other class C GPCRs in this process.

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Year:  2008        PMID： 18930324      PMCID： PMC3310155          DOI： 10.1016/j.tips.2008.09.002

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  49 in total

1.  A cell surface receptor mediates extracellular Ca(2+) sensing in guard cells.

Authors:  Shengcheng Han; Ruhang Tang; Lisa K Anderson; Todd E Woerner; Zhen-Ming Pei
Journal:  Nature       Date:  2003-09-11       Impact factor: 49.962

2.  Another dimension to calcium signaling: a look at extracellular calcium.

Authors:  Aldebaran M Hofer
Journal:  J Cell Sci       Date:  2005-03-01       Impact factor: 5.285

3.  Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor.

Authors:  M Bai; S Quinn; S Trivedi; O Kifor; S H Pearce; M R Pollak; K Krapcho; S C Hebert; E M Brown
Journal:  J Biol Chem       Date:  1996-08-09       Impact factor: 5.157

4.  A receptor activity modifying protein (RAMP)2-dependent adrenomedullin receptor is a calcitonin gene-related peptide receptor when coexpressed with human RAMP1.

Authors:  N Bühlmann; K Leuthäuser; R Muff; J A Fischer; W Born
Journal:  Endocrinology       Date:  1999-06       Impact factor: 4.736

5.  Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor.

Authors:  Gregor B Adams; Karissa T Chabner; Ian R Alley; Douglas P Olson; Zbigniew M Szczepiorkowski; Mark C Poznansky; Claudine H Kos; Martin R Pollak; Edward M Brown; David T Scadden
Journal:  Nature       Date:  2005-12-28       Impact factor: 49.962

6.  Calcium-sensing receptor dimerizes in the endoplasmic reticulum: biochemical and biophysical characterization of CASR mutants retained intracellularly.

Authors:  Svetlana Pidasheva; Michael Grant; Lucie Canaff; Oya Ercan; Ujendra Kumar; Geoffrey N Hendy
Journal:  Hum Mol Genet       Date:  2006-06-01       Impact factor: 6.150

7.  m-Calpain colocalizes with the calcium-sensing receptor (CaR) in caveolae in parathyroid cells and participates in degradation of the CaR.

Authors:  Olga Kifor; Imre Kifor; Francis D Moore; Robert R Butters; Edward M Brown
Journal:  J Biol Chem       Date:  2003-06-03       Impact factor: 5.157

8.  Generation and functional characterization of fluorescent, N-terminally tagged CB1 receptor chimeras for live-cell imaging.

Authors:  Neil A McDonald; Christopher M Henstridge; Christopher N Connolly; Andrew J Irving
Journal:  Mol Cell Neurosci       Date:  2007-03-03       Impact factor: 4.314

9.  Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals.

Authors:  M Ruat; M E Molliver; A M Snowman; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-11       Impact factor: 11.205

10.  Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism.

Authors:  M R Pollak; E M Brown; Y H Chou; S C Hebert; S J Marx; B Steinmann; T Levi; C E Seidman; J G Seidman
Journal:  Cell       Date:  1993-12-31       Impact factor: 41.582
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  15 in total

Review 1.  Small GTPase regulation of GPCR anterograde trafficking.

Authors:  Guansong Wang; Guangyu Wu
Journal:  Trends Pharmacol Sci       Date:  2011-10-17       Impact factor: 14.819

Review 2.  Mechanisms of multimodal sensing by extracellular Ca(2+)-sensing receptors: a domain-based survey of requirements for binding and signalling.

Authors:  Mahvash A Khan; Arthur D Conigrave
Journal:  Br J Pharmacol       Date:  2010-02-05       Impact factor: 8.739

3.  Interaction of actin with carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) receptor in liposomes is Ca2+- and phospholipid-dependent.

Authors:  Rongze Lu; Michiel J M Niesen; Weidong Hu; Nagarajan Vaidehi; John E Shively
Journal:  J Biol Chem       Date:  2011-06-13       Impact factor: 5.157

Review 4.  Regulation of post-Golgi traffic of G protein-coupled receptors.

Authors:  Guangyu Wu
Journal:  Subcell Biochem       Date:  2012

5.  Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension.

Authors:  Haiyang Tang; Aya Yamamura; Hisao Yamamura; Shanshan Song; Dustin R Fraidenburg; Jiwang Chen; Yali Gu; Nicole M Pohl; Tong Zhou; Laura Jiménez-Pérez; Ramon J Ayon; Ankit A Desai; David Goltzman; Franz Rischard; Zain Khalpey; Stephan M Black; Joe G N Garcia; Ayako Makino; Jason X J Yuan
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2016-03-11       Impact factor: 5.464

6.  Activation of calcitonin receptor and calcitonin receptor-like receptor by membrane-anchored ligands.

Authors:  Chia Lin Chang; Jae-Il Park; Sheau Yu Teddy Hsu
Journal:  J Biol Chem       Date:  2009-11-10       Impact factor: 5.157

7.  RAMP1 is a direct NKX3.1 target gene up-regulated in prostate cancer that promotes tumorigenesis.

Authors:  Monica Logan; Philip D Anderson; Shahrazad T Saab; Omar Hameed; Sarki A Abdulkadir
Journal:  Am J Pathol       Date:  2013-07-16       Impact factor: 4.307

8.  Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H.

Authors:  Wei-Chun Wei; Benjamin Jacobs; Esther B E Becker; Maike D Glitsch
Journal:  Proc Natl Acad Sci U S A       Date:  2015-08-10       Impact factor: 11.205

9.  Primary hyperparathyroidism in a patient with familial hypocalciuric hypercalcaemia due to a novel mutation in the calcium-sensing receptor gene.

Authors:  Aoife M Egan; James Ryan; Mardiana A Aziz; Tadhg P O'Dwyer; Maria M Byrne
Journal:  J Bone Miner Metab       Date:  2012-10-19       Impact factor: 2.626

10.  Presynaptic external calcium signaling involves the calcium-sensing receptor in neocortical nerve terminals.

Authors:  Wenyan Chen; Jeremy B Bergsman; Xiaohua Wang; Gawain Gilkey; Carol-Renée Pierpoint; Erin A Daniel; Emmanuel M Awumey; Philippe Dauban; Robert H Dodd; Martial Ruat; Stephen M Smith
Journal:  PLoS One       Date:  2010-01-05       Impact factor: 3.240
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