BACKGROUND: Alcohol dependence (AD) is costly to societies worldwide, moderately heritable, and genetically complex. Risk loci in several populations have been identified with genetic linkage analysis. To date, there has been no published linkage study of AD focused on African Americans (AAs). METHODS: We completed a genomewide linkage scan with approximately 6000 single nucleotide polymorphism markers to map loci increasing risk for DSM-IV AD in a set of 238 small nuclear families ascertained on the basis of multiple individuals affected with cocaine or opioid dependence. Model free linkage analysis was completed with Merlin software. A modified marker set was used to avoid bias due to markers in strong linkage disequilibrium. RESULTS: We identified a genomewide-significant linkage to markers near 117.2 centiMorgans on chromosome 10q23.3-24.1 (logarithm of odds score 3.32; p = 5.0E-05; empirical genomewide p = .033). CONCLUSIONS: These data add to the growing evidence for locations for AD risk loci and provide the first linkage evidence for such a locus in the AA population.
BACKGROUND:Alcohol dependence (AD) is costly to societies worldwide, moderately heritable, and genetically complex. Risk loci in several populations have been identified with genetic linkage analysis. To date, there has been no published linkage study of AD focused on African Americans (AAs). METHODS: We completed a genomewide linkage scan with approximately 6000 single nucleotide polymorphism markers to map loci increasing risk for DSM-IV AD in a set of 238 small nuclear families ascertained on the basis of multiple individuals affected with cocaine or opioid dependence. Model free linkage analysis was completed with Merlin software. A modified marker set was used to avoid bias due to markers in strong linkage disequilibrium. RESULTS: We identified a genomewide-significant linkage to markers near 117.2 centiMorgans on chromosome 10q23.3-24.1 (logarithm of odds score 3.32; p = 5.0E-05; empirical genomewide p = .033). CONCLUSIONS: These data add to the growing evidence for locations for AD risk loci and provide the first linkage evidence for such a locus in the AA population.
Authors: Kenneth S Kendler; Po-Hsiu Kuo; B Todd Webb; Gursharan Kalsi; Michael C Neale; Patrick F Sullivan; Dermot Walsh; Diana G Patterson; Brien Riley; Carol A Prescott Journal: Alcohol Clin Exp Res Date: 2006-12 Impact factor: 3.455
Authors: Xingguang Luo; Henry R Kranzler; Lingjun Zuo; Shuang Wang; Nicholas J Schork; Joel Gelernter Journal: Am J Hum Genet Date: 2006-04-11 Impact factor: 11.025
Authors: Joel Gelernter; Carolien Panhuysen; Roger Weiss; Kathleen Brady; James Poling; Michael Krauthammer; Lindsay Farrer; Henry R Kranzler Journal: Biol Psychiatry Date: 2006-11-01 Impact factor: 13.382
Authors: C A Prescott; P F Sullivan; P-H Kuo; B T Webb; J Vittum; D G Patterson; D L Thiselton; J M Myers; M Devitt; L J Halberstadt; V P Robinson; M C Neale; E J van den Oord; D Walsh; B P Riley; K S Kendler Journal: Mol Psychiatry Date: 2006-06 Impact factor: 15.992
Authors: Amira Pierucci-Lagha; Joel Gelernter; Grace Chan; Albert Arias; Joseph F Cubells; Lindsay Farrer; Henry R Kranzler Journal: Drug Alcohol Depend Date: 2007-06-27 Impact factor: 4.492
Authors: Po-Hsiu Kuo; Gursharan Kalsi; Carol A Prescott; Colin A Hodgkinson; David Goldman; Edwin J van den Oord; Jeffry Alexander; Cizhong Jiang; Patrick F Sullivan; Diana G Patterson; Dermot Walsh; Kenneth S Kendler; Brien P Riley Journal: Alcohol Clin Exp Res Date: 2008-03-04 Impact factor: 3.455
Authors: Yi Yu; Henry R Kranzler; Carolien Panhuysen; Roger D Weiss; James Poling; Lindsay A Farrer; Joel Gelernter Journal: Hum Genet Date: 2008-04-26 Impact factor: 4.132
Authors: Arpana Agrawal; Anthony L Hinrichs; Gerald Dunn; Sarah Bertelsen; Danielle M Dick; Scott F Saccone; Nancy L Saccone; Richard A Grucza; Jen C Wang; C Robert Cloninger; Howard J Edenberg; Tatiana Foroud; Victor Hesselbrock; John Kramer; Kathleen K Bucholz; Samuel Kuperman; John I Nurnberger; Bernice Porjesz; Marc A Schuckit; Alison M Goate; Laura J Bierut Journal: Drug Alcohol Depend Date: 2007-10-17 Impact factor: 4.492
Authors: Mark Zlojutro; Niklas Manz; Madhavi Rangaswamy; Xiaoling Xuei; Leah Flury-Wetherill; Daniel Koller; Laura J Bierut; Alison Goate; Victor Hesselbrock; Samuel Kuperman; John Nurnberger; John P Rice; Marc A Schuckit; Tatiana Foroud; Howard J Edenberg; Bernice Porjesz; Laura Almasy Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2010-11-02 Impact factor: 3.568
Authors: Alexis C Edwards; Fazil Aliev; Laura J Bierut; Kathleen K Bucholz; Howard Edenberg; Victor Hesselbrock; John Kramer; Samuel Kuperman; John I Nurnberger; Marc A Schuckit; Bernice Porjesz; Danielle M Dick Journal: Psychiatr Genet Date: 2012-02 Impact factor: 2.458
Authors: Pingxing Xie; Henry R Kranzler; James Poling; Murray B Stein; Raymond F Anton; Kathleen Brady; Roger D Weiss; Lindsay Farrer; Joel Gelernter Journal: Arch Gen Psychiatry Date: 2009-11