| Literature DB >> 18930108 |
Adela Zdarilova1, Eva Vrublova, Jitka Vostalova, Borivoj Klejdus, David Stejskal, Jitka Proskova, Pavel Kosina, Alena Svobodova, Rostislav Vecera, Jan Hrbac, Drahomira Cernochova, Jaroslav Vicar, Jitka Ulrichova, Vilim Simanek.
Abstract
Macleaya cordata (Willd.) (Papaveraceae) is used as an active component in the natural feed additive Sangrovit. Sangrovit contains mixture of the intact aerial parts and the fraction of quaternary benzo[c]phenanthridine alkaloids from M. cordata (FQBA). In a 90-day pilot toxicity trial, Sangrovit and the FQBA were tested for safety. Male Wistar rats were fed for 90 days with 100, 7000 or 14000mg of Sangrovit or 600mg of FQBA in 1kg of feed. Body and organ weights, clinical chemistry and hematology markers, oxidative stress parameters, morphological structure of tongue, liver, ileum, kidney and heart samples, and total cytochrome P450 in liver were monitored. The results showed no statistically significant alterations in any parameter between control and treated animals, except for the group treated with 14000ppm Sangrovit that resulted in elevation of reduced glutathione level and superoxide dismutase activity in liver.Entities:
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Year: 2008 PMID： 18930108 DOI： 10.1016/j.fct.2008.09.054
Source DB: PubMed Journal: Food Chem Toxicol ISSN： 0278-6915 Impact factor: 6.023