PURPOSE: Certain Y-chromosomal lineages have been suggested to predispose individuals to prostate cancer in the Japanese population; in other ethnic groups, however, the importance of the Y chromosome is poorly understood. EXPERIMENTAL DESIGN: To assess the possible Y-chromosomal contribution to prostate cancer risk and prognosis, we analyzed five binary Y-chromosomal markers in 1,447 prostate cancer cases and 983 population controls from the Swedish population. Together, these five markers capture the vast majority of chromosome Y haplogroup diversity in the Swedish population. Individual lineages were tested for association with both prostate cancer risk and cancer-specific death. We replicated observed associations in an independent Swedish prostate cancer case-control study comprising 1,452 cases and 779 controls. RESULTS: One rare lineage (I1c) was associated with an increased risk of developing prostate cancer [odds ratio (OR), 2.9; 95% confidence interval (CI), 1.4-5.8; P = 0.001]. However, confirmatory analysis of this lineage in the independent case-control study revealed no association with prostate cancer risk (OR, 0.65; 95% CI, 0.4-1.2, P = 0.17). We observed no association between chromosome Y variation and prostate cancer-specific death. CONCLUSIONS: This study provides strong evidence against an important role of the Y chromosome in the initiation or outcome of prostate cancer in the Swedish population.
PURPOSE: Certain Y-chromosomal lineages have been suggested to predispose individuals to prostate cancer in the Japanese population; in other ethnic groups, however, the importance of the Y chromosome is poorly understood. EXPERIMENTAL DESIGN: To assess the possible Y-chromosomal contribution to prostate cancer risk and prognosis, we analyzed five binary Y-chromosomal markers in 1,447 prostate cancer cases and 983 population controls from the Swedish population. Together, these five markers capture the vast majority of chromosome Y haplogroup diversity in the Swedish population. Individual lineages were tested for association with both prostate cancer risk and cancer-specific death. We replicated observed associations in an independent Swedish prostate cancer case-control study comprising 1,452 cases and 779 controls. RESULTS: One rare lineage (I1c) was associated with an increased risk of developing prostate cancer [odds ratio (OR), 2.9; 95% confidence interval (CI), 1.4-5.8; P = 0.001]. However, confirmatory analysis of this lineage in the independent case-control study revealed no association with prostate cancer risk (OR, 0.65; 95% CI, 0.4-1.2, P = 0.17). We observed no association between chromosome Y variation and prostate cancer-specific death. CONCLUSIONS: This study provides strong evidence against an important role of the Y chromosome in the initiation or outcome of prostate cancer in the Swedish population.
Authors: Lisa A Cannon-Albright; James M Farnham; Matthew Bailey; Frederick S Albright; Craig C Teerlink; Neeraj Agarwal; Robert A Stephenson; Alun Thomas Journal: Prostate Date: 2014-05-06 Impact factor: 4.104
Authors: Zhaoming Wang; Hemang Parikh; Jinping Jia; Timothy Myers; Meredith Yeager; Kevin B Jacobs; Amy Hutchinson; Laurie Burdett; Arpita Ghosh; Michael J Thun; Susan M Gapstur; W Ryan Diver; Jarmo Virtamo; Demetrius Albanes; Geraldine Cancel-Tassin; Antoine Valeri; Olivier Cussenot; Kenneth Offit; Ed Giovannucci; Jing Ma; Meir J Stampfer; J Michael Gaziano; David J Hunter; Ana Dutra-Clarke; Tomas Kirchhoff; Michael Alavanja; Laura B Freeman; Stella Koutros; Robert Hoover; Sonja I Berndt; Richard B Hayes; Ilir Agalliu; Robert D Burk; Sholom Wacholder; Gilles Thomas; Laufey Amundadottir Journal: Hum Genet Date: 2012-01-24 Impact factor: 4.132
Authors: A Mesut Erzurumluoglu; Denis Baird; Tom G Richardson; Nicholas J Timpson; Santiago Rodriguez Journal: Genes (Basel) Date: 2018-01-22 Impact factor: 4.096