Literature DB >> 18927272

Alphav integrins lead the way for colorectal metastases.

Joseph H McCarty1.   

Abstract

In this issue of Clinical Cancer Research, Conti et al. identify a crucial cell adhesion and signaling axis that promotes the proliferation, survival, and drug-resistant properties of metastatic colorectal cancer cells in the liver. The components of this pathway may be effective targets for therapeutically treating established metastatic tumors in patients with colorectal adenocarcinomas.

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Year:  2008        PMID： 18927272      PMCID： PMC2688736          DOI： 10.1158/1078-0432.CCR-08-1847

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  13 in total

Review 1.  Roles of alphav integrins in vascular biology and pulmonary pathology.

Authors:  Dean Sheppard
Journal:  Curr Opin Cell Biol       Date:  2004-10       Impact factor: 8.382

2.  Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma.

Authors:  Thomas Armstrong; Graham Packham; Lindsay B Murphy; Adrian C Bateman; John A Conti; David R Fine; Colin D Johnson; R Christopher Benyon; John P Iredale
Journal:  Clin Cancer Res       Date:  2004-11-01       Impact factor: 12.531

Review 3.  Integrins: bidirectional, allosteric signaling machines.

Authors:  Richard O Hynes
Journal:  Cell       Date:  2002-09-20       Impact factor: 41.582

4.  Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death.

Authors:  Joseph H McCarty; Adam Lacy-Hulbert; Alain Charest; Roderick T Bronson; Denise Crowley; David Housman; John Savill; Jürgen Roes; Richard O Hynes
Journal:  Development       Date:  2004-12-02       Impact factor: 6.868

Review 5.  Biology of colorectal liver metastases.

Authors:  Syed A Ahmad; Russell S Berman; Lee M Ellis
Journal:  Surg Oncol Clin N Am       Date:  2003-01       Impact factor: 3.495

6.  Integrin alpha v beta 6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver.

Authors:  Guang-Yun Yang; Ke-Sen Xu; Zhong-Qing Pan; Zhao-Yang Zhang; Yue-Tang Mi; Jin-Shen Wang; Rong Chen; Jun Niu
Journal:  Cancer Sci       Date:  2008-02-18       Impact factor: 6.716

Review 7.  Basement membranes: structure, assembly and role in tumour angiogenesis.

Authors:  Raghu Kalluri
Journal:  Nat Rev Cancer       Date:  2003-06       Impact factor: 60.716

Review 8.  Alpha-v integrins as therapeutic targets in oncology.

Authors:  Jeffrey A Nemeth; Marian T Nakada; M Trikha; Zhihui Lang; Michael S Gordon; Gordon C Jayson; Robert Corringham; Uma Prabhakar; Hugh M Davis; Robert A Beckman
Journal:  Cancer Invest       Date:  2007-10       Impact factor: 2.176

Review 9.  Liver fibrosis.

Authors:  Karen Wallace; Alastair D Burt; Matthew C Wright
Journal:  Biochem J       Date:  2008-04-01       Impact factor: 3.857

10.  Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma.

Authors:  Joseph H McCarty; Marc Barry; Denise Crowley; Roderick T Bronson; Adam Lacy-Hulbert; Richard O Hynes
Journal:  Am J Pathol       Date:  2008-05-08       Impact factor: 4.307
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  6 in total

Review 1.  αvβ8 integrin adhesion and signaling pathways in development, physiology and disease.

Authors:  Joseph H McCarty
Journal:  J Cell Sci       Date:  2020-06-15       Impact factor: 5.285

2.  Adenoviruses with an αvβ integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases.

Authors:  Sergio Lavilla-Alonso; Gerd Bauerschmitz; Usama Abo-Ramadan; Juha Halavaara; Sophie Escutenaire; Iulia Diaconu; Turgut Tatlisumak; Anna Kanerva; Akseli Hemminki; Sari Pesonen
Journal:  J Transl Med       Date:  2010-08-23       Impact factor: 5.531

3.  Regulation of integrin αV subunit expression by sulfatide in hepatocellular carcinoma cells.

Authors:  Wei Wu; Yi Wei Dong; Peng Cheng Shi; Mei Yu; Da Fu; Chun Yi Zhang; Qian Qian Cai; Qian Lei Zhao; Ming Peng; Li Hui Wu; Xing Zhong Wu
Journal:  J Lipid Res       Date:  2013-01-22       Impact factor: 5.922

4.  Prognostic value of β1 integrin expression in colorectal liver metastases.

Authors:  Nikolaos Vassos; Tilman Rau; Susanne Merkel; Fabian Feiersinger; Carol I Geppert; Michael Stürzl; Werner Hohenberger; Roland S Croner
Journal:  Int J Clin Exp Pathol       Date:  2013-12-15

5.  Targeted in vivo imaging of integrin alphavbeta6 with an improved radiotracer and its relevance in a pancreatic tumor model.

Authors:  Sven H Hausner; Craig K Abbey; Richard J Bold; M Karen Gagnon; Jan Marik; John F Marshall; Cathy E Stanecki; Julie L Sutcliffe
Journal:  Cancer Res       Date:  2009-06-23       Impact factor: 12.701

6.  LncRNA AY promotes hepatocellular carcinoma metastasis by stimulating ITGAV transcription.

Authors:  Chun Lan Kang; Bing Qi; Qian Qian Cai; Li Sheng Fu; Ying Yang; Chang Tang; Ping Zhu; Qi Wen Chen; Jing Pan; Mei Hua Chen; Xing Zhong Wu
Journal:  Theranostics       Date:  2019-06-09       Impact factor: 11.556
  6 in total

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