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Literature DB >> 18927204

The role of FXR in disorders of bile acid homeostasis.

Jyrki J Eloranta¹, Gerd A Kullak-Ublick.

Abstract

As ligands for the nuclear receptor FXR, bile acids regulate their own synthesis, transport, and conjugation, thus protecting against bile acid toxicity. Recently, the role of genetic variants in FXR itself, FXR target genes, and regulators of FXR in the pathophysiology of the liver and intestine has become increasingly evident.

Entities: Chemical Disease Gene

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Year: 2008 PMID： 18927204 DOI： 10.1152/physiol.00020.2008

Source DB: PubMed Journal: Physiology (Bethesda) ISSN： 1548-9221

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Cited

34 in total

1. FXR silencing in human colon cancer by DNA methylation and KRAS signaling.

Authors: Ann M Bailey; Le Zhan; Dipen Maru; Imad Shureiqi; Curtis R Pickering; Galina Kiriakova; Julie Izzo; Nan He; Caimiao Wei; Veerabhadran Baladandayuthapani; Han Liang; Scott Kopetz; Garth Powis; Grace L Guo
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2013-10-31 Impact factor: 4.052

2. Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice.

Authors: Prachi Borude; Genea Edwards; Chad Walesky; Feng Li; Xiaochao Ma; Bo Kong; Grace L Guo; Udayan Apte
Journal: Hepatology Date: 2012-12 Impact factor: 17.425

3. Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes.

Authors: Natarajan Balasubramaniyan; Meena Ananthanarayanan; Frederick J Suchy
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2012-02-16 Impact factor: 4.052

4. Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor.

Authors: Xiulong Song; Yuan Chen; Leila Valanejad; Rajani Kaimal; Bingfang Yan; Matthew Stoner; Ruitang Deng
Journal: J Lipid Res Date: 2013-09-03 Impact factor: 5.922

The role of FXR in disorders of bile acid homeostasis.

1. FXR silencing in human colon cancer by DNA methylation and KRAS signaling.

2. Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice.

3. Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes.

4. Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor.

Review 5. The impact of farnesoid X receptor activation on intestinal permeability in inflammatory bowel disease.

Review 6. Cross-talk between bile acids and intestinal microbiota in host metabolism and health.

Review 7. Blood-Bile Barrier: Morphology, Regulation, and Pathophysiology.

8. Bile acid-induced arrhythmia is mediated by muscarinic M2 receptors in neonatal rat cardiomyocytes.

Review 9. Organic anion-transporting polypeptides.

Review 10. Bile acids: regulation of synthesis.