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Literature DB >> 18926698

Synthesis of Arabino glycosyl triazoles as potential inhibitors of mycobacterial cell wall biosynthesis.

Brendan L Wilkinson¹, Hilary Long, Edith Sim, Antony J Fairbanks.

Abstract

A series of arabino glycosyl triazoles with varying hydrophobic groups were synthesised as putative mimics of decaprenolphosphoarabinose (DPA) as potential inhibitors of mycobacterial cell wall biosynthesis. Biological testing against Mycobacterium bovis BCG revealed low to moderate anti-mycobacterial activity, with strong dependence on the identity of the hydrophobic side chain.

Entities: Chemical Species

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Year: 2008 PMID： 18926698 DOI： 10.1016/j.bmcl.2008.09.082

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

5 in total

1. Anti-bacterial glycosyl triazoles - Identification of an N-acetylglucosamine derivative with bacteriostatic activity against Bacillus.

Authors: Helene Kuhn; Danielle Gutelius; Eimear Black; Christina Nadolny; Amit Basu; Christopher Reid
Journal: Medchemcomm Date: 2014-08 Impact factor: 3.597

5. Potential Inhibitors of Galactofuranosyltransferase 2 (GlfT2): Molecular Docking, 3D-QSAR, and In Silico ADMETox Studies.

Authors: Christopher Llynard D Ortiz; Gladys C Completo; Ruel C Nacario; Ricky B Nellas
Journal: Sci Rep Date: 2019-11-19 Impact factor: 4.379

5 in total

Synthesis of Arabino glycosyl triazoles as potential inhibitors of mycobacterial cell wall biosynthesis.

1. Anti-bacterial glycosyl triazoles - Identification of an N-acetylglucosamine derivative with bacteriostatic activity against Bacillus.

2. Organocatalyzed preparation of 1,4,5-trisubstituted-glycosyl-1,2,3-triazole derivatives.

3. β-D-Arabinosyl 1-C-sulfonic acid^.

4. 'Click chemistry' synthesis of 1-(α-D-mannopyranosyl)-1,2,3-triazoles for inhibition of α-mannosidases.

5. Potential Inhibitors of Galactofuranosyltransferase 2 (GlfT2): Molecular Docking, 3D-QSAR, and In Silico ADMETox Studies.

Synthesis of Arabino glycosyl triazoles as potential inhibitors of mycobacterial cell wall biosynthesis.

1. Anti-bacterial glycosyl triazoles - Identification of an N-acetylglucosamine derivative with bacteriostatic activity against Bacillus.

2. Organocatalyzed preparation of 1,4,5-trisubstituted-glycosyl-1,2,3-triazole derivatives.

3. β-D-Arabinosyl 1-C-sulfonic acid.

4. 'Click chemistry' synthesis of 1-(α-D-mannopyranosyl)-1,2,3-triazoles for inhibition of α-mannosidases.

5. Potential Inhibitors of Galactofuranosyltransferase 2 (GlfT2): Molecular Docking, 3D-QSAR, and In Silico ADMETox Studies.

3. β-D-Arabinosyl 1-C-sulfonic acid^.