Literature DB >> 18926286

From expression to signaling: roles of TREM-1 and TREM-2 in innate immunity and bacterial infection.

Omar Sharif1, Sylvia Knapp.   

Abstract

Triggering receptor expressed on myeloid cells (TREM) proteins play important roles in innate and adaptive immunity. Since the discovery of TREM-1 and TREM-2 in 2000, the field has exploded over the past 8 years and currently TREM-1 is thought of as an amplifier of the immune response, while TREM-2 is believed to be a negative regulator. Here, we discuss the current state of the literature on TREMs, with a focus on TREM-1 and TREM-2 and their expression, signaling in mononuclear phagocytes and roles in innate immunity and bacterial infection.

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Year:  2008        PMID： 18926286     DOI： 10.1016/j.imbio.2008.07.008

Source DB:  PubMed          Journal:  Immunobiology        ISSN： 0171-2985            Impact factor:   3.144


  96 in total

Review 1.  Triggering receptor expressed on myeloid cells receptor family modulators: a patent review.

Authors:  Christopher J Pelham; Amit N Pandya; Devendra K Agrawal
Journal:  Expert Opin Ther Pat       Date:  2014-11-01       Impact factor: 6.674

2.  TREM-1 expression in rat corneal epithelium with Aspergillus fumigatus infection.

Authors:  Li-Ting Hu; Zhao-Dong Du; Gui-Qiu Zhao; Sheng Qiu; Nan Jiang; Jing Lin; Qian Wang; Qiang Xu
Journal:  Int J Ophthalmol       Date:  2015-04-18       Impact factor: 1.779

3.  Dynamic changes in serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and its gene polymorphisms are associated with sepsis prognosis.

Authors:  Longxiang Su; Changting Liu; Cong Li; Zhaoxu Jiang; Kun Xiao; Xin Zhang; Ming Li; Peng Yan; Dan Feng; Lixin Xie
Journal:  Inflammation       Date:  2012-12       Impact factor: 4.092

4.  TREM-1 as a potential therapeutic target in neonatal sepsis.

Authors:  Lei Qian; Xiao-Wen Weng; Wei Chen; Chang-Hong Sun; Jian Wu
Journal:  Int J Clin Exp Med       Date:  2014-07-15

5.  Impact of cigarette smoke on the human and mouse lungs: a gene-expression comparison study.

Authors:  Mathieu C Morissette; Maxime Lamontagne; Jean-Christophe Bérubé; Gordon Gaschler; Andrew Williams; Carole Yauk; Christian Couture; Michel Laviolette; James C Hogg; Wim Timens; Sabina Halappanavar; Martin R Stampfli; Yohan Bossé
Journal:  PLoS One       Date:  2014-03-24       Impact factor: 3.240

Review 6.  TREM and TREM-like receptors in inflammation and disease.

Authors:  Jill W Ford; Daniel W McVicar
Journal:  Curr Opin Immunol       Date:  2009-02-21       Impact factor: 7.486

7.  TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection.

Authors:  Lígia Antunes Gonçalves; Lurdes Rodrigues-Duarte; Joana Rodo; Luciana Vieira de Moraes; Isabel Marques; Carlos Penha-Gonçalves
Journal:  Proc Natl Acad Sci U S A       Date:  2013-11-11       Impact factor: 11.205

8.  TREM-1 Attenuates RIPK3-mediated Necroptosis in Hyperoxia-induced Lung Injury in Neonatal Mice.

Authors:  Mansoor Ali Syed; Dilip Shah; Pragnya Das; Sture Andersson; Gloria Pryhuber; Vineet Bhandari
Journal:  Am J Respir Cell Mol Biol       Date:  2019-03       Impact factor: 6.914

9.  TREM-2 promotes host resistance against Pseudomonas aeruginosa infection by suppressing corneal inflammation via a PI3K/Akt signaling pathway.

Authors:  Mingxia Sun; Min Zhu; Kang Chen; Xinxin Nie; Qiuchan Deng; Linda D Hazlett; Yongjian Wu; Meiyu Li; Minhao Wu; Xi Huang
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-05-17       Impact factor: 4.799

10.  Activation of the TREM-1 pathway in human monocytes by periodontal pathogens and oral commensal bacteria.

Authors:  M Varanat; E M Haase; J G Kay; F A Scannapieco
Journal:  Mol Oral Microbiol       Date:  2016-09-06       Impact factor: 3.563
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