Literature DB >> 18925999

An unusual case of warfarin-induced pinna skin necrosis.

M Martinez Del Pero1, S Verma, A Espeso, M Griffiths, P Jani.   

Abstract

INTRODUCTION: Warfarin-induced skin necrosis is a rare but recognised complication of this drug. The condition predominantly affects the breasts, buttocks and thighs of obese, peri-menopausal women. We present the case of a patient with the condition in an unusual site, and we discuss the management challenges involved. CASE REPORT: An 82-year-old man presented to the ENT department with a diagnosis of pinna haematoma. There was no history of trauma or infection. The patient was taking warfarin long-term for recurrent deep vein thrombosis. Two weeks prior to admission, the patient had had a loading course of warfarin following surgery. Multiple clinical teams were involved in treatment. The only abnormal laboratory investigation was a low protein S level; biopsy showed skin necrosis.
CONCLUSION: In this case, the unusual presentation created diagnostic confusion, and may have precipitated aggressive surgical debridement. However, a more conservative management strategy was used, which we would recommend in future.

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Year:  2008        PMID: 18925999     DOI: 10.1017/S0022215108003903

Source DB:  PubMed          Journal:  J Laryngol Otol        ISSN: 0022-2151            Impact factor:   1.469


  2 in total

1.  Warfarin-induced skin necrosis.

Authors:  Catherine R Mungalsingh; Jamie Bomford; Jeremy Nayagam; Mirella Masiello; Ugo I Ekeowa; Simon Webster
Journal:  Clin Med (Lond)       Date:  2012-02       Impact factor: 2.659

2.  Stent thrombosis caused by metal allergy complicated by protein S deficiency and heparin-induced thrombocytopenia: a case report and review of the literature.

Authors:  Takao Konishi; Tadashi Yamamoto; Naohiro Funayama; Beni Yamaguchi; Seiichiro Sakurai; Hiroshi Nishihara; Koko Yamazaki; Yusuke Kashiwagi; Yasuki Sasa; Mitsuru Gima; Hideichi Tanaka; Daisuke Hotta; Kenjiro Kikuchi
Journal:  Thromb J       Date:  2015-07-23
  2 in total

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