OBJECTIVE: To analyze the distribution of HLA-B alleles and to investigate their contribution in the susceptibility to spondyloarthropathies (SpA) in a sample population from Zambia, in order to determine a relationship between some HLA-B alleles and development of ankylosing spondylitis (AS), reactive arthritis (ReA), or undifferentiated SpA (uSpA). METHODS: . We selected 72 patients with SpA and found that 46 had uSpA, 23 ReA, and 3 AS. We also selected 92 matched controls; 55 of these had human immunodeficiency virus type I (HIV-I) infection. RESULTS: We found a significant increase in the rate of uSpA and ReA with features of Reiter's syndrome (RS) in HIV-positive individuals who carried the HLA-B*5703 allele (pc < 0.0001 and pc < 0.001, respectively). Among the significant new findings identified were the presence of B*1403 in 2 of the 3 AS patients (pc < 0.05, OR 47), confirming previous data in the Togolese population. CONCLUSION: The presence of B*5703 and HIV infection may not affect susceptibility to AS and ReA, but they do show an important influence in uSpA and RS. Our findings confirm that HLA-B*1403 is the only factor to increase the risk of AS in a sub-Saharan African population, whereas HLA-B27 was virtually absent in patients with AS.
OBJECTIVE: To analyze the distribution of HLA-B alleles and to investigate their contribution in the susceptibility to spondyloarthropathies (SpA) in a sample population from Zambia, in order to determine a relationship between some HLA-B alleles and development of ankylosing spondylitis (AS), reactive arthritis (ReA), or undifferentiated SpA (uSpA). METHODS: . We selected 72 patients with SpA and found that 46 had uSpA, 23 ReA, and 3 AS. We also selected 92 matched controls; 55 of these had human immunodeficiency virus type I (HIV-I) infection. RESULTS: We found a significant increase in the rate of uSpA and ReA with features of Reiter's syndrome (RS) in HIV-positive individuals who carried the HLA-B*5703 allele (pc < 0.0001 and pc < 0.001, respectively). Among the significant new findings identified were the presence of B*1403 in 2 of the 3 AS patients (pc < 0.05, OR 47), confirming previous data in the Togolese population. CONCLUSION: The presence of B*5703 and HIV infection may not affect susceptibility to AS and ReA, but they do show an important influence in uSpA and RS. Our findings confirm that HLA-B*1403 is the only factor to increase the risk of AS in a sub-Saharan African population, whereas HLA-B27 was virtually absent in patients with AS.
Authors: Pravin Kumar; Ardeschir Vahedi-Faridi; Wolfram Saenger; Elena Merino; José A López de Castro; Barbara Uchanska-Ziegler; Andreas Ziegler Journal: J Biol Chem Date: 2009-07-18 Impact factor: 5.157
Authors: Isabel Legaz; Jose Miguel Bolarín; Elena Navarro; Jose Antonio Campillo; Rosa Moya; María Dolores Pérez-Cárceles; Aurelio Luna; Eduardo Osuna; Manuel Miras; Manuel Muro; Alfredo Minguela; Rocio Alvarez López Journal: Arch Med Sci Date: 2019-04-09 Impact factor: 3.318
Authors: Adrian Cortes; Sara L Pulit; Paul J Leo; Jenny J Pointon; Philip C Robinson; Michael H Weisman; Michael Ward; Lianne S Gensler; Xiaodong Zhou; Henri-Jean Garchon; Gilles Chiocchia; Johannes Nossent; Benedicte A Lie; Øystein Førre; Jaakko Tuomilehto; Kari Laiho; Linda A Bradbury; Dirk Elewaut; Ruben Burgos-Vargas; Simon Stebbings; Louise Appleton; Claire Farrah; Jonathan Lau; Nigil Haroon; Juan Mulero; Francisco J Blanco; Miguel A Gonzalez-Gay; C Lopez-Larrea; Paul Bowness; Karl Gaffney; Hill Gaston; Dafna D Gladman; Proton Rahman; Walter P Maksymowych; J Bart A Crusius; Irene E van der Horst-Bruinsma; Raphael Valle-Oñate; Consuelo Romero-Sánchez; Inger Myrnes Hansen; Fernando M Pimentel-Santos; Robert D Inman; Javier Martin; Maxime Breban; Bryan Paul Wordsworth; John D Reveille; David M Evans; Paul I W de Bakker; Matthew A Brown Journal: Nat Commun Date: 2015-05-21 Impact factor: 14.919