UNLABELLED: Cardiovascular complications are the main cause of morbidity and mortality among patients with CKD. It is common knowledge that in atherogenesis the disorders of calcium--phosphate metabolism count. The molecules of paramount importance are OPN and BMP-7, inhibiting calcification, and PDGF-BB, facilitating this process. THE AIM OF THE STUDY: to assess the concentrations of the above mentioned factors and their correlation with other markers of atherogenesis in children with CKD. MATERIAL AND METHODS: OPN, PDGF-BB and BMP-7 plasma concentrations were assessed by ELISA in 18 patients with CKD (stage: I-IV) and in 12 patients from the control group. Ca-P parameters and the lipid profile were also estimated in both groups. RESULTS: OPN concentrations were comparable in both groups. PDGF-BB median values were lower (p < 0.05) and BMP-7 concentrations--higher in CKD patients than in the controls (p < 0.005). The PDGF-BB concentrations correlated negatively with OPN (R = -0.75, p < 0.001) and CRP (R = -0.71, p < 0.05) in CKD children. The negative correlation was also observed between OPN concentrations and hematocrit (R = -0.49, p < 0.04) and hemoglobin (R = -0.48, p < 0.04) values. In all patients the levels of Ca, P, alkaline phosphatase and PTH were within the normal range. CONCLUSIONS: The increase of BMP-7 concentrations and decrease of PDGF-BB values in children with CKD, coexisting with well controlled Ca-P metabolism parameters, may suggest early mobilization of mechanisms protecting against vascular calcification. These changes seem independent of dyslipidemia.
UNLABELLED: Cardiovascular complications are the main cause of morbidity and mortality among patients with CKD. It is common knowledge that in atherogenesis the disorders of calcium--phosphate metabolism count. The molecules of paramount importance are OPN and BMP-7, inhibiting calcification, and PDGF-BB, facilitating this process. THE AIM OF THE STUDY: to assess the concentrations of the above mentioned factors and their correlation with other markers of atherogenesis in children with CKD. MATERIAL AND METHODS:OPN, PDGF-BB and BMP-7 plasma concentrations were assessed by ELISA in 18 patients with CKD (stage: I-IV) and in 12 patients from the control group. Ca-P parameters and the lipid profile were also estimated in both groups. RESULTS:OPN concentrations were comparable in both groups. PDGF-BB median values were lower (p < 0.05) and BMP-7 concentrations--higher in CKD patients than in the controls (p < 0.005). The PDGF-BB concentrations correlated negatively with OPN (R = -0.75, p < 0.001) and CRP (R = -0.71, p < 0.05) in CKD children. The negative correlation was also observed between OPN concentrations and hematocrit (R = -0.49, p < 0.04) and hemoglobin (R = -0.48, p < 0.04) values. In all patients the levels of Ca, P, alkaline phosphatase and PTH were within the normal range. CONCLUSIONS: The increase of BMP-7 concentrations and decrease of PDGF-BB values in children with CKD, coexisting with well controlled Ca-P metabolism parameters, may suggest early mobilization of mechanisms protecting against vascular calcification. These changes seem independent of dyslipidemia.