Literature DB >> 18922889

Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling.

Fabio Petrocca1, Andrea Vecchione, Carlo M Croce.   

Abstract

Inactivation of the transforming growth factor beta (TGFbeta) tumor suppressor pathway is a main step in the development of a variety of human tumors. The miR-106b-25 and miR-17-92 clusters are emerging as key modulators of TGFbeta signaling in gastrointestinal and other tumors, interfering with cell cycle arrest and apoptosis when overexpressed in cancer cells. Genetic ablation of these microRNAs (miRNAs) reveals their physiologic role in the control of liver and central nervous system apoptosis, supporting the notion that miRNA-based homeostatic mechanisms can be usurped by cancer cells to resist TGFbeta tumor suppression.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18922889     DOI： 10.1158/0008-5472.CAN-08-1768

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  185 in total

1.  Two miRNA clusters, Mir-17-92 (Mirc1) and Mir-106b-25 (Mirc3), are involved in the regulation of spermatogonial differentiation in mice.

Authors:  Ming-Han Tong; Debra Ann Mitchell; Samantha Dawn McGowan; Ryan Evanoff; Michael D Griswold
Journal:  Biol Reprod       Date:  2012-03-19       Impact factor: 4.285

Review 2.  MicroRNAs in autophagy and their emerging roles in crosstalk with apoptosis.

Authors:  Jianzhen Xu; Yanfei Wang; Xiaorong Tan; Hongjuan Jing
Journal:  Autophagy       Date:  2012-03-23       Impact factor: 16.016

3.  microRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways.

Authors:  Olga Kovalchuk; Franz J Zemp; Jody N Filkowski; Alvin M Altamirano; Jennifer S Dickey; Gloria Jenkins-Baker; Stephen A Marino; David J Brenner; William M Bonner; Olga A Sedelnikova
Journal:  Carcinogenesis       Date:  2010-07-19       Impact factor: 4.944

4.  The effect of antisense inhibitor of miRNA 106b∼25 on the proliferation, invasion, migration, and apoptosis of gastric cancer cell.

Authors:  Rupeng Zhang; Fangxuan Li; Weijia Wang; Xuejun Wang; Shixia Li; Juntian Liu
Journal:  Tumour Biol       Date:  2016-02-05

5.  High iodine blocks a Notch/miR-19 loop activated by the BRAF(V600E) oncoprotein and restores the response to TGFβ in thyroid follicular cells.

Authors:  Cesar Seigi Fuziwara; Edna Teruko Kimura
Journal:  Thyroid       Date:  2014-01-29       Impact factor: 6.568

6.  Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells.

Authors:  Amit Kumar Srivastava; Chunhua Han; Ran Zhao; Tiantian Cui; Yuntao Dai; Charlene Mao; Weiqiang Zhao; Xiaoli Zhang; Jianhua Yu; Qi-En Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-23       Impact factor: 11.205

7.  MicroRNA and transcription factor mediated regulatory network for ovarian cancer: regulatory network of ovarian cancer.

Authors:  Huanchun Ying; Jing Lv; Tianshu Ying; Jun Li; Qing Yang; Yuan Ma
Journal:  Tumour Biol       Date:  2013-08-29

Review 8.  Epigenetics: novel mechanism of pulmonary hypertension.

Authors:  Jing-bin Huang; Jian Liang; Xiao-fang Zhao; Wen-sen Wu; Fu Zhang
Journal:  Lung       Date:  2013-09-20       Impact factor: 2.584

Review 9.  The microRNA networks of TGFβ signaling in cancer.

Authors:  V P Sivadas; S Kannan
Journal:  Tumour Biol       Date:  2013-12-10

10.  Differential microRNA profile and post-transcriptional regulation exist in systemic lupus erythematosus patients with distinct autoantibody specificities.

Authors:  Sudhir Kumar Chauhan; Vikas Vikram Singh; Richa Rai; Madhukar Rai; Geeta Rai
Journal:  J Clin Immunol       Date:  2014-05       Impact factor: 8.317
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.