Literature DB >> 18922693

2-Aryloxymethylmorpholine histamine H(3) antagonists.

Michael A Letavic1, John M Keith, Kiev S Ly, Pascal Bonaventure, Mark A Feinstein, Brian Lord, Kirsten L Miller, S Timothy Motley, Diane Nepomuceno, Steven W Sutton, Nicholas I Carruthers.   

Abstract

The synthesis and biological activity of a new series of 2-aryloxymethylmorpholine histamine H(3) antagonists is described. The new compounds are high affinity histamine H(3) ligands that penetrate the CNS and occupy the histamine H(3) receptor in rat brain.

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Year:  2008        PMID： 18922693     DOI： 10.1016/j.bmcl.2008.09.077

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development.

Authors:  Michael A Letavic; Leah Aluisio; Richard Apodaca; Manoj Bajpai; Ann J Barbier; Anne Bonneville; Pascal Bonaventure; Nicholas I Carruthers; Christine Dugovic; Ian C Fraser; Michelle L Kramer; Brian Lord; Timothy W Lovenberg; Lilian Y Li; Kiev S Ly; Heather Mcallister; Neelakandha S Mani; Kirsten L Morton; Anthony Ndifor; S Diane Nepomuceno; Chennagiri R Pandit; Steven B Sands; Chandra R Shah; Jonathan E Shelton; Sandra S Snook; Devin M Swanson; Wei Xiao
Journal:  ACS Med Chem Lett       Date:  2015-03-13       Impact factor: 4.345

2.  Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [¹¹C]GSK189254 in anesthetized baboon.

Authors:  Jean Logan; Nicholas I Carruthers; Michael A Letavic; Steven Sands; Xiaohui Jiang; Colleen Shea; Lisa Muench; Youwen Xu; Pauline Carter; Payton King; Joanna S Fowler
Journal:  Psychopharmacology (Berl)       Date:  2012-05-22       Impact factor: 4.530
  2 in total

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