Literature DB >> 18922122

Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver physiology.

Catherine Cavard1, Sabine Colnot, Virginie Audard, Samira Benhamouche, Laetitia Finzi, Cyril Torre, Gisèle Grimber, Cécile Godard, Benoit Terris, Christine Perret.   

Abstract

The Wnt/beta-catenin pathway is a key developmental pathway for which alterations have been described in various human cancers. The aberrant activation of this pathway is a major event in human hepatocellular carcinoma. Several laboratories have shown that the Wnt/beta-catenin pathway plays an essential role in all phases of liver development and maturation, and is required for the metabolic function of this organ. In this review, we summarize current knowledge regarding the role of the Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver biology, and the possibilities for developing new therapeutic interventions based on this knowledge.

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Year:  2008        PMID： 18922122     DOI： 10.2217/14796694.4.5.647

Source DB:  PubMed          Journal:  Future Oncol        ISSN： 1479-6694            Impact factor:   3.404


  30 in total

1.  Downregulation of RIP140 in hepatocellular carcinoma promoted the growth and migration of the cancer cells.

Authors:  Dexiang Zhang; Yueqi Wang; Yuedi Dai; Jiwen Wang; Tao Suo; Hongtao Pan; Han Liu; Sheng Shen; Houbao Liu
Journal:  Tumour Biol       Date:  2014-11-13

2.  Hepatitis B virus X (HBx) play an anti-apoptosis role in hepatic progenitor cells by activating Wnt/β-catenin pathway.

Authors:  Lihong Shen; Xifeng Zhang; Daixi Hu; Tao Feng; Hongli Li; Yongliang Lu; Jiayi Huang
Journal:  Mol Cell Biochem       Date:  2013-08-10       Impact factor: 3.396

3.  Musashi-2 promotes hepatitis Bvirus related hepatocellular carcinoma progression via the Wnt/β-catenin pathway.

Authors:  Ming-Hai Wang; Shi-Yong Qin; Shu-Guang Zhang; Guang-Xin Li; Zhen-Hai Yu; Kun Wang; Bin Wang; Mu-Jian Teng; Zhi-Hai Peng
Journal:  Am J Cancer Res       Date:  2015-02-15       Impact factor: 6.166

Review 4.  Liver zonation: Novel aspects of its regulation and its impact on homeostasis.

Authors:  Rolf Gebhardt; Madlen Matz-Soja
Journal:  World J Gastroenterol       Date:  2014-07-14       Impact factor: 5.742

Review 5.  The role of Hedgehog signaling in fibrogenic liver repair.

Authors:  Steve S Choi; Alessia Omenetti; Wing-Kin Syn; Anna Mae Diehl
Journal:  Int J Biochem Cell Biol       Date:  2010-11-05       Impact factor: 5.085

6.  HNF4α-Deficient Fatty Liver Provides a Permissive Environment for Sex-Independent Hepatocellular Carcinoma.

Authors:  Baharan Fekry; Aleix Ribas-Latre; Corrine Baumgartner; Alaa M T Mohamed; Mikhail G Kolonin; Frances M Sladek; Mamoun Younes; Kristin L Eckel-Mahan
Journal:  Cancer Res       Date:  2019-10-01       Impact factor: 12.701

7.  Depletion of β-catenin from mature hepatocytes of mice promotes expansion of hepatic progenitor cells and tumor development.

Authors:  Er-Yea Wang; Shiou-Hwei Yeh; Ting-Fen Tsai; Hsiang-Po Huang; Yung-Ming Jeng; Wei-Hsiang Lin; Wei-Chih Chen; Kun-Huei Yeh; Pei-Jer Chen; Ding-Shinn Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-31       Impact factor: 11.205

8.  TCTP promotes glioma cell proliferation in vitro and in vivo via enhanced β-catenin/TCF-4 transcription.

Authors:  Xuefeng Gu; Lifen Yao; Guoda Ma; Lili Cui; You Li; Wandong Liang; Bin Zhao; Keshen Li
Journal:  Neuro Oncol       Date:  2013-12-04       Impact factor: 12.300

Review 9.  Clinical implications of cancer stem cell biology in hepatocellular carcinoma.

Authors:  Junfang Ji; Xin Wei Wang
Journal:  Semin Oncol       Date:  2012-08       Impact factor: 4.929

10.  Evaluation of Apelin/APJ system expression in hepatocellular carcinoma as a function of clinical severity.

Authors:  Manuela Cabiati; Melania Gaggini; Paolo De Simone; Silvia Del Ry
Journal:  Clin Exp Med       Date:  2020-11-17       Impact factor: 3.984
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