Literature DB >> 1890551

Histopathological studies on the local reactions induced by complete Freund's adjuvant (CFA), bacterial lipopolysaccharide (LPS), and synthetic lipopeptide (P3C) conjugates.

F Wiedemann1, R Link, K Pumpe, U Jacobshagen, H E Schaefer, K H Wiesmüller, R P Hummel, G Jung, W Bessler, T Böltz.   

Abstract

The inflammatory reactions following subcutaneous application of adjuvants revealed characteristic pathological patterns. The injection of complete Freund's adjuvant (CFA) resulted in the formation of large lipid deposits encircled by an inflammatory reaction and concentrically arranged collagen bundles. Bacterial lipopolysaccharide (LPS) caused granulomatous aggregations of mononuclear cells with thrombotic vessel occlusions. Inoculation of the lipopeptide adjuvants induced accumulation of mononuclear cells with only minimal fibrotic changes which were resolved after day 28. Lipopeptide conjugates based on the head group tripalmitoyl-S-glyceryl-cysteinyl-serin (P3CS) can thus be used as effective immunogens and adjuvants without long-term tissue damage.

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Year:  1991        PMID： 1890551     DOI： 10.1002/path.1711640313

Source DB:  PubMed          Journal:  J Pathol        ISSN： 0022-3417            Impact factor:   7.996


  9 in total

1.  [Lipopeptides as natural adjuvants for vaccines from Gram-negative bacteria].

Authors:  S Schlecht; K H Wiesmüller; G Jung; W G Bessler
Journal:  Naturwissenschaften       Date:  1993-01

2.  Immunostimulation by the synthetic lipopeptide P3CSK4: TLR4-independent activation of the ERK1/2 signal transduction pathway in macrophages.

Authors:  M R Müller; S D Pfannes; M Ayoub; P Hoffmann; W G Bessler; K Mittenbühler
Journal:  Immunology       Date:  2001-05       Impact factor: 7.397

3.  Intranasal administration of a synthetic lipopeptide without adjuvant induces systemic immune responses.

Authors:  Lbachir BenMohamed; Radhika Krishnan; Catherine Auge; James F Primus; Don J Diamond
Journal:  Immunology       Date:  2002-05       Impact factor: 7.397

4.  CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity.

Authors:  Nader Ghasemlou; Isaac M Chiu; Jean-Pierre Julien; Clifford J Woolf
Journal:  Proc Natl Acad Sci U S A       Date:  2015-11-23       Impact factor: 11.205

5.  Dermal inflammation elicited by synthetic analogs of Treponema pallidum and Borrelia burgdorferi lipoproteins.

Authors:  M V Norgard; B S Riley; J A Richardson; J D Radolf
Journal:  Infect Immun       Date:  1995-04       Impact factor: 3.441

6.  Spinal Cord Injury Suppresses Cutaneous Inflammation: Implications for Peripheral Wound Healing.

Authors:  Jessica M Marbourg; Anna Bratasz; Xiaokui Mo; Phillip G Popovich
Journal:  J Neurotrauma       Date:  2016-10-17       Impact factor: 5.269

7.  The mast cell activator compound 48/80 is safe and effective when used as an adjuvant for intradermal immunization with Bacillus anthracis protective antigen.

Authors:  Afton L McGowen; Laura P Hale; Christopher P Shelburne; Soman N Abraham; Herman F Staats
Journal:  Vaccine       Date:  2009-04-14       Impact factor: 3.641

8.  IMT504 Provides Analgesia by Modulating Cell Infiltrate and Inflammatory Milieu in a Chronic Pain Model.

Authors:  Candelaria Leiguarda; Constanza Potilinski; Julia Rubione; Pablo Tate; Marcelo J Villar; Alejandro Montaner; Verónica Bisagno; Luis Constandil; Pablo R Brumovsky
Journal:  J Neuroimmune Pharmacol       Date:  2020-11-21       Impact factor: 4.147

Review 9.  Targeting the porcine immune system--particulate vaccines in the 21st century.

Authors:  Kenneth C McCullough; Artur Summerfield
Journal:  Dev Comp Immunol       Date:  2008-09-02       Impact factor: 3.636
  9 in total

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