Literature DB >> 1890207

Inhibition of urease activity but not growth of Helicobacter pylori by acetohydroxamic acid.

J Goldie1, S J Veldhuyzen van Zanten, S Jalali, H Richardson, R H Hunt.   

Abstract

The in vitro effects of acetohydroxamic acid (AHA), a potent urease inhibitor, were studied to determine the effect on the urease activity and growth of 38 strains of Helicobacter pylori. AHA in concentrations of 50-1000 mg/l had a noticeably reversible inhibitory effect on the urease activity of the organism but no effect on growth.

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Year:  1991        PMID： 1890207      PMCID： PMC496771          DOI： 10.1136/jcp.44.8.695

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  10 in total

1.  Urease inhibitors for hepatic coma. II. Comparative efficacy of four lower hydroxamate homologs in vitro and in vivo.

Authors:  W N Fishbein; J E Daly
Journal:  Proc Soc Exp Biol Med       Date:  1970-09

2.  Synthesis and metabolism of labeled acetohydroxamic acid, a urease inhibitor.

Authors:  E Wolpert; A F Hofmann; W H Summerskill
Journal:  Proc Soc Exp Biol Med       Date:  1971-02

3.  Urease activity and antibiotic sensitivity of bacteria.

Authors:  G R Gale
Journal:  J Bacteriol       Date:  1966-02       Impact factor: 3.490

4.  Inhibition of urease activity by hydroxamic acid derivatives of amino acids.

Authors:  K Kobashi; S Takebe; N Terashima; J Hase
Journal:  J Biochem       Date:  1975-04       Impact factor: 3.387

5.  Acetohydroxamate: bacterial urease inhibitor with therapeutic potential in hyperammonaemic states.

Authors:  W N Fishbein; P P Carbone; H D Hochstein
Journal:  Nature       Date:  1965-10-02       Impact factor: 49.962

6.  Interaction between acetohydroxamic acid and 12 antibiotics against 14 gram-negative pathogenic bacteria.

Authors:  D M Musher; C Saenz; D P Griffith
Journal:  Antimicrob Agents Chemother       Date:  1974-02       Impact factor: 5.191

7.  Optimization of a medium for the rapid urease test for detection of Campylobacter pylori in gastric antral biopsies.

Authors:  J Goldie; S J Veldhuyzen van Zanten; S Jalali; J Hollingsworth; R H Riddell; H Richardson; R H Hunt
Journal:  J Clin Microbiol       Date:  1989-09       Impact factor: 5.948

8.  A randomized double-blind study of acetohydroxamic acid in struvite nephrolithiasis.

Authors:  J J Williams; J S Rodman; C M Peterson
Journal:  N Engl J Med       Date:  1984-09-20       Impact factor: 91.245

9.  Campylobacter pyloridis, urease, hydrogen ion back diffusion, and gastric ulcers.

Authors:  S L Hazell; A Lee
Journal:  Lancet       Date:  1986-07-05       Impact factor: 79.321

10.  Characterization of urease from Campylobacter pylori.

Authors:  H L Mobley; M J Cortesia; L E Rosenthal; B D Jones
Journal:  J Clin Microbiol       Date:  1988-05       Impact factor: 5.948
  10 in total
  3 in total

1.  Urease activity of Helicobacter pylori.

Authors:  K Kobashi
Journal:  J Clin Pathol       Date:  1992-04       Impact factor: 3.411

2.  Antibacterial action of the urease inhibitor acetohydroxamic acid on Helicobacter pylori.

Authors:  K Phillips; D J Munster; R A Allardyce; P F Bagshaw
Journal:  J Clin Pathol       Date:  1993-04       Impact factor: 3.411

3.  Ultrastructural localization of urease of Helicobacter pylori.

Authors:  G Bode; P Malfertheiner; G Lehnhardt; M Nilius; H Ditschuneit
Journal:  Med Microbiol Immunol       Date:  1993-11       Impact factor: 3.402
  3 in total

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