Literature DB >> 1890200

Use of monoclonal antibodies to recognise osteoclasts in routinely processed bone biopsy specimens.

N A Athanasou1, B Puddle, J Quinn, C G Woods.   

Abstract

In decalcified (5% nitric acid) and undecalcified (glycol-methacrylate or resin embedded) routinely processed bone specimens osteoclasts against resorbing surfaces were identified with monoclonal antibodies directed against leucocyte common antigen (LCA) (PD7/26, 2B11), CD68 (KP1), and gpIIIa (Y2/51) but not against HLA-DR (CR3/43 and Ta11B5). Mononuclear cells on resorbing surfaces and occasional mononuclear cells against or near resting surfaces showed a similar pattern of reactivity. This study shows that immunohistochemistry is a sensitive and useful technique for identifying osteoclasts in routinely processed bone specimens. It also suggests a role for mononuclear cells (possibly pre-osteoclasts) in bone resorption.

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Year:  1991        PMID： 1890200      PMCID： PMC496760          DOI： 10.1136/jcp.44.8.664

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  15 in total

1.  New sites of cellular vitronectin receptor immunoreactivity detected with osteoclast-reacting monoclonal antibodies 13C2 and 23C6.

Authors:  N A Athanasou; J Quinn; M A Horton; J O McGee
Journal:  Bone Miner       Date:  1990-01

2.  Immunophenotypic differences between osteoclasts and macrophage polykaryons: immunohistological distinction and implications for osteoclast ontogeny and function.

Authors:  N A Athanasou; J Quinn
Journal:  J Clin Pathol       Date:  1990-12       Impact factor: 3.411

3.  Plastic embedding of transbronchial biopsy specimens for light microscopy.

Authors:  C W Edwards; A Krypczyk; A Brownhill
Journal:  J Clin Pathol       Date:  1979-12       Impact factor: 3.411

4.  The immunohistological detection of platelets, megakaryocytes and thrombi in routinely processed specimens.

Authors:  K C Gatter; J L Cordell; H Turley; A Heryet; N Kieffer; D J Anstee; D Y Mason
Journal:  Histopathology       Date:  1988-09       Impact factor: 5.087

5.  Use of monoclonal antibodies for the histopathological diagnosis of human malignancy.

Authors:  K C Gatter; Z Abdulaziz; P Beverley; J R Corvalan; C Ford; E B Lane; M Mota; J R Nash; K Pulford; H Stein; J Taylor-Papadimitriou; C Woodhouse; D Y Mason
Journal:  J Clin Pathol       Date:  1982-11       Impact factor: 3.411

6.  Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.

Authors:  M A Horton; D Lewis; K McNulty; J A Pringle; T J Chambers
Journal:  Cancer Res       Date:  1985-11       Impact factor: 12.701

7.  Glycol methacrylate as an embedding medium for bone.

Authors:  M Hott; P J Marie
Journal:  Stain Technol       Date:  1987-01

8.  Generation of osteoclastic function in mouse bone marrow cultures: multinuclearity and tartrate-resistant acid phosphatase are unreliable markers for osteoclastic differentiation.

Authors:  G Hattersley; T J Chambers
Journal:  Endocrinology       Date:  1989-04       Impact factor: 4.736

9.  A monoclonal antibody that detects HLA-D region antigen in routinely fixed, wax embedded sections of normal and neoplastic lymphoid tissues.

Authors:  A A Epenetos; L G Bobrow; T E Adams; C M Collins; P G Isaacson; W F Bodmer
Journal:  J Clin Pathol       Date:  1985-01       Impact factor: 3.411

10.  Diagnosis of human lymphoma with monoclonal antileukocyte antibodies.

Authors:  R A Warnke; K C Gatter; B Falini; P Hildreth; R E Woolston; K Pulford; J L Cordell; B Cohen; C De Wolf-Peeters; D Y Mason
Journal:  N Engl J Med       Date:  1983-11-24       Impact factor: 91.245
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  6 in total

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Authors:  K Piper; A Boyde; S J Jones
Journal:  Anat Embryol (Berl)       Date:  1992-09

2.  Immunophenotype of multinucleated and mononuclear cells in giant cell lesions of bone and soft tissue.

Authors:  I A Doussis; B Puddle; N A Athanasou
Journal:  J Clin Pathol       Date:  1992-05       Impact factor: 3.411

3.  Complement and the recruitment of mononuclear osteoclasts.

Authors:  D C Mangham; D J Scoones; M T Drayson
Journal:  J Clin Pathol       Date:  1993-06       Impact factor: 3.411

Review 4.  New insights into the pathogenesis and genetics of psoriatic arthritis.

Authors:  Kristine E Nograles; Richard D Brasington; Anne M Bowcock
Journal:  Nat Clin Pract Rheumatol       Date:  2009-02

5.  Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts.

Authors:  Jason W Ashley; Zhenqi Shi; Haibo Zhao; Xingsheng Li; Robert A Kesterson; Xu Feng
Journal:  PLoS One       Date:  2011-10-03       Impact factor: 3.240

6.  Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism.

Authors:  Gustaf Wigerblad; Duygu B Bas; Cátia Fernades-Cerqueira; Akilan Krishnamurthy; Kutty Selva Nandakumar; Katarzyna Rogoz; Jungo Kato; Katalin Sandor; Jie Su; Juan Miguel Jimenez-Andrade; Anja Finn; Alex Bersellini Farinotti; Khaled Amara; Karin Lundberg; Rikard Holmdahl; Per-Johan Jakobsson; Vivianne Malmström; Anca I Catrina; Lars Klareskog; Camilla I Svensson
Journal:  Ann Rheum Dis       Date:  2015-11-27       Impact factor: 19.103
  6 in total

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