Literature DB >> 1889746

Characterization of the opposite-strand genes from the mouse bidirectionally transcribed HTF9 locus.

A Bressan1, M P Somma, J Lewis, C Santolamazza, N G Copeland, D J Gilbert, N A Jenkins, P Lavia.   

Abstract

The mouse HTF9 locus contains two genes that are bidirectionally transcribed with opposite polarity from a shared CpG-rich island. Both genes were previously shown to be expressed in a housekeeping fashion in mouse. We have now determined the molecular organization of the genes over 12 kb surrounding the island. In addition, we show that the HTF9 locus resides in the proximal region of mouse chromosome 16. We have sequenced the cDNAs corresponding to both divergent transcripts. Both genes appear to code for novel proteins that are structurally unrelated to each other. Finally, we show that both genes are highly conserved and efficiently expressed in human cells.

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Year:  1991        PMID： 1889746     DOI： 10.1016/0378-1119(91)90274-f

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  11 in total

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2.  Expression of the murine RanBP1 and Htf9-c genes is regulated from a shared bidirectional promoter during cell cycle progression.

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Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

3.  Characterization of Lactococcus lactis UV-sensitive mutants obtained by ISS1 transposition.

Authors:  P Duwat; A Cochu; S D Ehrlich; A Gruss
Journal:  J Bacteriol       Date:  1997-07       Impact factor: 3.490

4.  Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway.

Authors:  M Künzler; T Gerstberger; F Stutz; F R Bischoff; E Hurt
Journal:  Mol Cell Biol       Date:  2000-06       Impact factor: 4.272

5.  Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization.

Authors:  A Puech; B Saint-Jore; B Funke; D J Gilbert; H Sirotkin; N G Copeland; N A Jenkins; R Kucherlapati; B Morrow; A I Skoultchi
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-23       Impact factor: 11.205

6.  The Ran/TC4 GTPase-binding domain: identification by expression cloning and characterization of a conserved sequence motif.

Authors:  A L Beddow; S A Richards; N R Orem; I G Macara
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-11       Impact factor: 11.205

7.  Cell type-specific interactions of transcription factors with a housekeeping promoter in vivo.

Authors:  G Stapleton; M P Somma; P Lavia
Journal:  Nucleic Acids Res       Date:  1993-05-25       Impact factor: 16.971

8.  Systematic analysis of head-to-head gene organization: evolutionary conservation and potential biological relevance.

Authors:  Yuan-Yuan Li; Hui Yu; Zong-Ming Guo; Ting-Qing Guo; Kang Tu; Yi-Xue Li
Journal:  PLoS Comput Biol       Date:  2006-05-15       Impact factor: 4.475

9.  Mutants in a yeast Ran binding protein are defective in nuclear transport.

Authors:  G Schlenstedt; D H Wong; D M Koepp; P A Silver
Journal:  EMBO J       Date:  1995-11-01       Impact factor: 11.598

10.  Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1.

Authors:  F R Bischoff; H Krebber; E Smirnova; W Dong; H Ponstingl
Journal:  EMBO J       Date:  1995-02-15       Impact factor: 11.598
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