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Literature DB >> 188579

Alteration of lymphocyte subpopulations with cytomegalovirus infection in infancy.

Abstract

The distribution of immunoglobulin bearing (Ig+), T, and null lymphocyte subpopulations and the lymphocyte response to phytohaemagglutinin (PHA) and pokeweed mitogen (PWM) were determined in three infants with cytomegalovirus (CMV) infection. These infants had significantly decreased percentages of T cells (13%, 29% and 40%) compared to age-matched controls (61 +/- 2%). Compensatory increases in the percentages of Ig+ and null cells occurred. Decreased lymphocyte reactivity to PHA and PWM occurred in two patients. Purified T cells from these patients had normal reactivity indicating a disproportion of T cells in the peripheral blood. These abnormalities may result from CMV infection of lymphocytes and could be responsible for prolonged CMV viruria.

Entities: Disease Species

Mesh：

Substances：
Immunoglobulins

Year: 1976 PMID： 188579 PMCID： PMC1540970

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

15 in total

1. Immune deficiency in congenital rubella and other viral infections.

Authors: M A South; J R Montgomery; W E Rawls
Journal: Birth Defects Orig Artic Ser Date: 1975

2. Lymphoid cell necrosis, thymic atrophy, and growth retardation in newborn mice inoculated with murine cytomegalovirus.

Authors: J N Schwartz; C A Daniels; G K Klintworth
Journal: Am J Pathol Date: 1975-06 Impact factor: 4.307

2. Acute cytomegalovirus infection and the host immune response. II. Relationship of suppressed in vitro lymphocyte reactivity to bacterial recall antigens and mitogens with the development of cytomegalovirus-induced lymphocyte reactivity.

Authors: C H ten Napel; T H The
Journal: Clin Exp Immunol Date: 1980-02 Impact factor: 4.330

6. Elimination of nonspecific cytomegalovirus immunoglobulin M activities in the enzyme-linked immunosorbent assay by using anti-human immunoglobulin G.

Authors: L Joassin; M Reginster
Journal: J Clin Microbiol Date: 1986-03 Impact factor: 5.948

7. Immunological sequelae of intrauterine infection.

Authors: D N McMurray; H Rey
Journal: Clin Exp Immunol Date: 1981-05 Impact factor: 4.330

7 in total

Alteration of lymphocyte subpopulations with cytomegalovirus infection in infancy.

1. Immune deficiency in congenital rubella and other viral infections.

2. Lymphoid cell necrosis, thymic atrophy, and growth retardation in newborn mice inoculated with murine cytomegalovirus.

3. Depression of cell-mediated immunity during acute infectious mononucleosis.

4. Congenital cytomegalovirus infection: a fifteen year perspective.

5. Immunological responses to early and late intrauterine virus infections.

6. Immunologic abnormalities induced by postperfusion cytomegalovirus infection.

7. Decreased rosette-forming lymphocytes in malnutrition and intrauterine growth retardation.

8. Immunoglobulin concentrations in newborn infants with congenital cytomegalic inclusion disease.

9. Effect of murine cytomegalovirus on the in vitro responses of T and B cells to mitogens.

10. Chronic cytomegalovirus infection, immunodeficiency, and monoclonal gammopathy-antigen-driven malignancy?

Review 1. The murine cytomegalovirus as a model for the study of viral pathogenesis and persistent infections.

2. Acute cytomegalovirus infection and the host immune response. II. Relationship of suppressed in vitro lymphocyte reactivity to bacterial recall antigens and mitogens with the development of cytomegalovirus-induced lymphocyte reactivity.

3. Susceptibility of lymphoblastoid cells to infection with human cytomegalovirus.

4. Effect of concurrent cytomegaloviral infection and undernutrition on the growth and immune response of mice.

5. Effect of murine cytomegalovirus infection on mitogen responses in genetically resistant and susceptible mice.

6. Elimination of nonspecific cytomegalovirus immunoglobulin M activities in the enzyme-linked immunosorbent assay by using anti-human immunoglobulin G.

7. Immunological sequelae of intrauterine infection.