| Literature DB >> 1885718 |
P E Hoaksey1, K Awadzi, S A Ward, P A Coventry, M L Orme, G Edwards.
Abstract
A sensitive and selective reversed-phase high-performance liquid chromatographic method for the determination of albendazole and its active metabolite albendazole sulphoxide in plasma has been developed. It involves single-step extraction of plasma with dichloromethane, evaporation of the solvent and chromatography on a muBondapak phenyl column with a mobile phase of water containing 1% (v/v) triethylamine-methanol-acetonitrile (70:10:20, v/v) at pH 3.1. Run time is 12 min. The assay satisfies all of the criteria required for use in clinical pharmacokinetic studies and possesses important advantages, notably speed and expense, over current methods.Entities:
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Year: 1991 PMID： 1885718 DOI： 10.1016/0378-4347(91)80131-u
Source DB: PubMed Journal: J Chromatogr