Literature DB >> 18855740

Synthesis of marine natural products with antimalarial activity.

Ines Mancini1, Graziano Guella, Andrea Defant.   

Abstract

The role played by synthetic organic chemistry of marine metabolites as potential leads for drug discovery of antimalarial agents is discussed. Syntheses of the most promising molecules are summarized, with emphasis on structure-activity relationship (SAR) studies and their mechanism of action.

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Year:  2008        PMID： 18855740     DOI： 10.2174/138955708786141007

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  4 in total

1.  Anti-malarial, anti-trypanosomal, and anti-leishmanial activities of jacaranone isolated from Pentacalia desiderabilis (Vell.) Cuatrec. (Asteraceae).

Authors:  Thiago R Morais; Paulete Romoff; Oriana A Fávero; Juliana Q Reimão; Walkyria C Lourenço; André G Tempone; Angelica D Hristov; Silvia M Di Santi; João Henrique G Lago; Patricia Sartorelli; Marcelo J P Ferreira
Journal:  Parasitol Res       Date:  2011-05-26       Impact factor: 2.289

2.  Alkenyl Isocyanide Conjugate Additions: A Rapid Route to γ-Carbolines.

Authors:  Sergiy V Chepyshev; J Armando Lujan-Montelongo; Allen Chao; Fraser F Fleming
Journal:  Angew Chem Int Ed Engl       Date:  2017-03-13       Impact factor: 15.336

Review 3.  Marine antimalarials.

Authors:  Ernesto Fattorusso; Orazio Taglialatela-Scafati
Journal:  Mar Drugs       Date:  2009-04-23       Impact factor: 5.118

Review 4.  Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products.

Authors:  Alexander O Terent'ev; Dmitry A Borisov; Vera A Vil'; Valery M Dembitsky
Journal:  Beilstein J Org Chem       Date:  2014-01-08       Impact factor: 2.883
  4 in total

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