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Literature DB >> 18855731

Design of selective G-quadruplex ligands as potential anticancer agents.

Jia-Heng Tan¹, Lian-Quan Gu, Jian-Yong Wu.

Abstract

G-quadruplex structures are promising targets for design of cancer drugs with high selectivity and low toxicity. This review provides an update of the progress made over the last few years in the design of selective G-quadruplex ligands, and a comprehensive summary of the major design strategies and structural characteristics.

Entities: Disease

Mesh：

Substances：

Year: 2008 PMID： 18855731 DOI： 10.2174/138955708785909880

Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862

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Cited

8 in total

1. Synthesis and Evaluation of Quinazolone Derivatives as a New Class of c-KIT G-Quadruplex Binding Ligands.

Authors: Xiaoxiao Wang; Chen-Xi Zhou; Jin-Wu Yan; Jin-Qiang Hou; Shuo-Bin Chen; Tian-Miao Ou; Lian-Quan Gu; Zhi-Shu Huang; Jia-Heng Tan
Journal: ACS Med Chem Lett Date: 2013-08-13 Impact factor: 4.345

2. Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule.

Authors: Mekala Gunaratnam; Stephen Swank; Shozeb M Haider; Katja Galesa; Anthony P Reszka; Monica Beltran; Francisco Cuenca; Jonathan A Fletcher; Stephen Neidle
Journal: J Med Chem Date: 2009-06-25 Impact factor: 7.446

3. Insight into G-DNA structural polymorphism and folding from sequence and loop connectivity through free energy analysis.

Authors: Xiaohui Cang; Jiří Šponer; Thomas E Cheatham
Journal: J Am Chem Soc Date: 2011-08-19 Impact factor: 15.419

4. Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers.

Authors: Reza Ehsanian; Carter Van Waes; Stephan M Feller
Journal: Cell Commun Signal Date: 2011-05-15 Impact factor: 5.712

5. Finding and characterizing the complexes of drug like molecules with quadruplex DNA: combined use of an enhanced hydroxyl radical cleavage protocol and NMR.

Authors: Harikrushan Ranpura; Dobroslawa Bialonska; Philip H Bolton
Journal: PLoS One Date: 2014-04-24 Impact factor: 3.240

Design of selective G-quadruplex ligands as potential anticancer agents.

1. Synthesis and Evaluation of Quinazolone Derivatives as a New Class of c-KIT G-Quadruplex Binding Ligands.

2. Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule.

3. Insight into G-DNA structural polymorphism and folding from sequence and loop connectivity through free energy analysis.

4. Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers.

5. Finding and characterizing the complexes of drug like molecules with quadruplex DNA: combined use of an enhanced hydroxyl radical cleavage protocol and NMR.

6. Divalent Naphthalene Diimide Ligands Display High Selectivity for the Human Telomeric G-quadruplex in K⁺ Buffer.

7. The Interaction of Cyclic Naphthalene Diimide with G-Quadruplex under Molecular Crowding Condition.

8. Aminoglycosylation can enhance the G-quadruplex binding activity of epigallocatechin.