| Literature DB >> 18855724 |
Yan Lavrovsky1, Yan A Ivanenkov, Konstantin V Balakin, Darya A Medvedeva, Alexandre V Ivachtchenko.
Abstract
There has been considerable in vivo evidence that chemokine receptor CXCR4 and its endogenous ligand CXCL12 modulate some important physiological and pathophysiological processes, including cancer metastasis, angiogenesis, invasion, growth and progression. In this review we elucidate key aspects of CXCL12-CXCR4 signaling system with emphasis on peptide-based and small-molecule CXCR4 inhibitors.Entities:
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Year: 2008 PMID： 18855724 DOI： 10.2174/138955708785909907
Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862