Literature DB >> 18855404

A new one-pot, four-component synthesis of 1,2-amino alcohols: TiCl3/t-BuOOH-mediated radical hydroxymethylation of imines.

Angelo Clerici1, Alessandra Ghilardi, Nadia Pastori, Carlo Punta, Ombretta Porta.   

Abstract

An amine, an aldehyde, and methanol can be readily assembled in one pot under very mild conditions through a free-radical multicomponent reaction by using an aqueous acidic TiCl3/t-BuOOH system to afford 1,2-amino alcohols in fair to excellent yields.

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Year:  2008        PMID： 18855404     DOI： 10.1021/ol802244n

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Homogeneous and heterogeneous photoredox-catalyzed hydroxymethylation of ketones and keto esters: catalyst screening, chemoselectivity and dilution effects.

Authors:  Axel G Griesbeck; Melissa Reckenthäler
Journal:  Beilstein J Org Chem       Date:  2014-05-19       Impact factor: 2.883

2.  Multicomponent versus domino reactions: One-pot free-radical synthesis of β-amino-ethers and β-amino-alcohols.

Authors:  Bianca Rossi; Nadia Pastori; Simona Prosperini; Carlo Punta
Journal:  Beilstein J Org Chem       Date:  2015-01-15       Impact factor: 2.883

Review 3.  New advances in titanium-mediated free radical reactions.

Authors:  Bianca Rossi; Simona Prosperini; Nadia Pastori; Angelo Clerici; Carlo Punta
Journal:  Molecules       Date:  2012-12-11       Impact factor: 4.411
  3 in total

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