| Literature DB >> 18855214 |
Mehdi Babaei1, Mitra Emmami Abarghoei, Reza Ansari, Abbas Ali Vafaei, Abbas Ali Taherian, Maziar Mohammad Akhavan, Gafar Toussy, Shahrokh Mousavi.
Abstract
The effects of Thymus vulgaris hydroalcoholic extract on the contractile responses of the isolated guinea-pig ileum were investigated. Contraction changes in the terminal ileum of guinea pigs were monitored using a force displacement transducer amplifier connected to a physiograph. Thymus vulgaris extract inhibited the contractile responses in a dose-dependent manner and also decreased the amplitude of peristaltic waves. It is concluded that T. vulgaris has an antispasmodic action on guinea pig ileum by decreasing the amplitudes of the muscle contractions during peristalsis. The EC50 was calculated as 1.7 mg mL(-1). In guinea-pig ileum the extract led to an antispasmodic effect, possibly by affecting the anticholinergic and serotoninergic pathways.Entities:
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Year: 2008 PMID： 18855214 DOI： 10.1080/14786410601130257
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861