F Hofmann1, N Kralj. 1. Chair for Physiology Occupational Medicine and Prevention of Infectious diseases, University of Wuppertal, Gauss Str. 20, 42349, Wuppertal, Germany.
Abstract
BACKGROUND: Active immunization is the most important measure for controlling hepatitis B (HB) virus infection. The outcome of HB vaccination has been investigated in only a very small number of cohort studies, some of which found a number of cases of HBV infection. MATERIAL AND METHODS: Using a design different from that of earlier studies, we have investigated the occurrence of HBV infection and clinical HB disease in individuals who had a complete HB vaccination series. Reported cases of HB/HBV infections among 1235 German health care workers (HCW) were analyzed with special regard to the question of whether or not HB vaccination had taken place in the past. RESULTS: 23 persons had undergone a complete vaccination series with complete documentation: 18 were non-responders (post-vaccination anti-HBs < 10 IU/l), one was a low-responder (anti-HBs < 100 IU/l), and four were responders (100 IU/l).While all responders seroconverted without clinical sign of hepatitis, ten non-/low-responders contracted chronic HB/HBV infection and seven contracted self-limiting HB. CONCLUSION: Vaccination should be only regarded as "successful", if the post-vaccination anti-HBs concentration is at least 100 IU/l.
BACKGROUND: Active immunization is the most important measure for controlling hepatitis B (HB) virus infection. The outcome of HB vaccination has been investigated in only a very small number of cohort studies, some of which found a number of cases of HBV infection. MATERIAL AND METHODS: Using a design different from that of earlier studies, we have investigated the occurrence of HBV infection and clinical HB disease in individuals who had a complete HB vaccination series. Reported cases of HB/HBV infections among 1235 German health care workers (HCW) were analyzed with special regard to the question of whether or not HB vaccination had taken place in the past. RESULTS: 23 persons had undergone a complete vaccination series with complete documentation: 18 were non-responders (post-vaccination anti-HBs < 10 IU/l), one was a low-responder (anti-HBs < 100 IU/l), and four were responders (100 IU/l).While all responders seroconverted without clinical sign of hepatitis, ten non-/low-responders contracted chronic HB/HBV infection and seven contracted self-limiting HB. CONCLUSION: Vaccination should be only regarded as "successful", if the post-vaccination anti-HBs concentration is at least 100 IU/l.
Authors: S C Hadler; D P Francis; J E Maynard; S E Thompson; F N Judson; D F Echenberg; D G Ostrow; P M O'Malley; K A Penley; N L Altman Journal: N Engl J Med Date: 1986-07-24 Impact factor: 91.245
Authors: Sylvia M Kiertscher; Pallavi R Gangalum; Grace Ibrahim; Donald P Tashkin; Michael D Roth Journal: J Neuroimmune Pharmacol Date: 2018-01-16 Impact factor: 4.147