Literature DB >> 18854151

Stressing the brain, fattening the body.

Ling Yang1, Gökhan S Hotamisligil.   

Abstract

Obesity is characterized by chronic activation of inflammatory pathways in peripheral tissues. In this issue, Zhang et al. (2008) demonstrate that inflammation also occurs in the central nervous system where it disrupts activity of the hypothalamus leading to resistance to leptin that is mediated by activation of IKK and the endoplasmic reticulum stress response.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18854151     DOI： 10.1016/j.cell.2008.09.030

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  9 in total

1.  Sex-specific brain erythropoietin regulation of mouse metabolism and hypothalamic inflammation.

Authors:  Soumyadeep Dey; Zhenzhong Cui; Oksana Gavrilova; Xiaojie Zhang; Max Gassmann; Constance T Noguchi
Journal:  JCI Insight       Date:  2020-03-12

2.  Injury to hypothalamic Sim1 neurons is a common feature of obesity by exposure to high-fat diet in male and female mice.

Authors:  Eugene Nyamugenda; Marcus Trentzsch; Susan Russell; Tiffany Miles; Gunnar Boysen; Kevin D Phelan; Giulia Baldini
Journal:  J Neurochem       Date:  2019-02-11       Impact factor: 5.372

3.  Fasting induces an anti-inflammatory effect on the neuroimmune system which a high-fat diet prevents.

Authors:  Desiree N Lavin; Jennifer J Joesting; Gabriel S Chiu; Morgan L Moon; Jia Meng; Ryan N Dilger; Gregory G Freund
Journal:  Obesity (Silver Spring)       Date:  2011-04-28       Impact factor: 5.002

4.  Deletion of tumor necrosis factor-alpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis.

Authors:  Talita Romanatto; Erika A Roman; Ana P Arruda; Raphael G Denis; Carina Solon; Marciane Milanski; Juliana C Moraes; Maria L Bonfleur; Giovanna R Degasperi; Paty K Picardi; Sandro Hirabara; Antonio C Boschero; Rui Curi; Licio A Velloso
Journal:  J Biol Chem       Date:  2009-10-26       Impact factor: 5.157

Review 5.  Nutrient sensing and inflammation in metabolic diseases.

Authors:  Gökhan S Hotamisligil; Ebru Erbay
Journal:  Nat Rev Immunol       Date:  2008-12       Impact factor: 53.106

6.  Partial reversibility of hypothalamic dysfunction and changes in brain activity after body mass reduction in obese subjects.

Authors:  Simone van de Sande-Lee; Fabrício R S Pereira; Dennys E Cintra; Paula T Fernandes; Adilson R Cardoso; Célia R Garlipp; Eliton A Chaim; Jose C Pareja; Bruno Geloneze; Li Min Li; Fernando Cendes; Licio A Velloso
Journal:  Diabetes       Date:  2011-04-22       Impact factor: 9.461

7.  Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity.

Authors:  Dennys E Cintra; Eduardo R Ropelle; Juliana C Moraes; José R Pauli; Joseane Morari; Claudio T de Souza; Renato Grimaldi; Marcela Stahl; José B Carvalheira; Mario J Saad; Licio A Velloso
Journal:  PLoS One       Date:  2012-01-18       Impact factor: 3.240

8.  IEX-1 deficiency induces browning of white adipose tissue and resists diet-induced obesity.

Authors:  Mohd Shahid; Ammar A Javed; David Chandra; Haley E Ramsey; Dilip Shah; Mohammed F Khan; Liping Zhao; Mei X Wu
Journal:  Sci Rep       Date:  2016-04-11       Impact factor: 4.379

9.  Activation of nuclear factor kappa B pathway and reduction of hypothalamic oxytocin following hypothalamic lesions.

Authors:  Christian L Roth; Gabrielle D'Ambrosio; Clinton Elfers
Journal:  J Syst Integr Neurosci       Date:  2016-01-29
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.