Literature DB >> 18854134

NCAM is at the heart of reciprocal regulation of E-cadherin- and integrin-mediated adhesions via signaling modulation.

Margaret C Frame1, Gareth J Inman.   

Abstract

New work by Lehembre et al. in The EMBO Journal reveals that the cell-adhesion molecule, NCAM, is at the heart of crosstalk between E-cadherin loss and reciprocal focal adhesion assembly during the epithelial to mesenchymal transition (EMT). NCAM upregulation induces the formation of novel signaling complexes that correlate with NCAM-dependent focal adhesion assembly, migration, and cancer cell invasion.

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Year:  2008        PMID： 18854134     DOI： 10.1016/j.devcel.2008.09.016

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  13 in total

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Journal:  ASN Neuro       Date:  2016-11-22       Impact factor: 4.146

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