Literature DB >> 18854088

Alterations in the expression pattern of TCR zeta chain in T cells from patients with hematological diseases.

Yangqiu Li1.   

Abstract

The TCR zeta chain, a component of the T cell receptor (TCR)/CD3 complex, plays a significant role in the assembly of the receptor complex and in connecting antigen recognition to the intracellular signal transduction apparatus. Recently, studies have demonstrated altered expression and function of this signal transduction molecule in T cells from patients with hematological diseases. In this review, current knowledge concerning the biological feature and function of TCR zeta protein, splice variant and mutation of TCR zeta chain gene and alteration of expression pattern in hematological diseases and the related mechanism are summarized.

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Year:  2008        PMID： 18854088     DOI： 10.1179/102453308X343482

Source DB:  PubMed          Journal:  Hematology        ISSN： 1024-5332            Impact factor:   2.269


  14 in total

1.  Enhancement of the TCRζ expression, polyclonal expansion, and activation of t cells from patients with acute myeloid leukemia after IL-2, IL-7, and IL-12 induction.

Authors:  Li Shi; Shaohua Chen; Xianfeng Zha; Yan Xu; Ling Xu; Lijian Yang; Yuhong Lu; Kanger Zhu; Yangqiu Li
Journal:  DNA Cell Biol       Date:  2015-03-10       Impact factor: 3.311

2.  Upregulated TCRζ enhances interleukin-2 production in T-cells from patients with CML.

Authors:  Xianfeng Zha; Shaohua Chen; Lijian Yang; Li Shi; Bo Li; Xiuli Wu; Yuhong Lu; Yangqiu Li
Journal:  DNA Cell Biol       Date:  2012-10-11       Impact factor: 3.311

3.  Deletion with 25 nucleotides of TCRζ gene in T cells from a case with chronic myeloid leukemia.

Authors:  Yan Li; Jing Lai; Ziwei Liao; Lixin Guo; Bo Li; Kanger Zhu; Yangqiu Li
Journal:  Stem Cell Investig       Date:  2017-06-13

4.  Characteristics of TCRζ, ZAP-70, and FcɛRIγ gene expression in patients with T- and NK/T-cell lymphoma.

Authors:  Ziwei Liao; Lingling Zhou; Chunyan Wang; Zhifeng He; Xu Wang; Xiaodan Luo; Shaohua Chen; Lijian Yang; Huo Tan; Yangqiu Li
Journal:  DNA Cell Biol       Date:  2014-12-16       Impact factor: 3.311

5.  Higher PD-1 expression concurrent with exhausted CD8+ T cells in patients with de novo acute myeloid leukemia.

Authors:  Jiaxiong Tan; Shaohua Chen; Yuhong Lu; Danlin Yao; Ling Xu; Yikai Zhang; Lijian Yang; Jie Chen; Jing Lai; Zhi Yu; Kanger Zhu; Yangqiu Li
Journal:  Chin J Cancer Res       Date:  2017-10       Impact factor: 5.087

6.  Changes in the MALT1-A20-NF-κB expression pattern may be related to T cell dysfunction in AML.

Authors:  Li Shi; Shaohua Chen; Yuhong Lu; Xu Wang; Ling Xu; Fan Zhang; Lijian Yang; Xiuli Wu; Bo Li; Yangqiu Li
Journal:  Cancer Cell Int       Date:  2013-04-30       Impact factor: 5.722

7.  Altered expression of the TCR signaling related genes CD3 and FcεRIγ in patients with aplastic anemia.

Authors:  Bo Li; Sichu Liu; Yuzhe Niu; Su Fang; Xiuli Wu; Zhi Yu; Shaohua Chen; Lijian Yang; Yangqiu Li
Journal:  J Hematol Oncol       Date:  2012-03-08       Impact factor: 17.388

8.  Upregulated TCRζ improves cytokine secretion in T cells from patients with AML.

Authors:  Shaohua Chen; Xianfeng Zha; Li Shi; Lingling Zhou; Lijian Yang; Bo Li; Xiuli Wu; Jun Zhong; Tao Zhang; Yuhong Lu; Kanger Zhu; Yangqiu Li
Journal:  J Hematol Oncol       Date:  2015-06-18       Impact factor: 17.388

9.  New insights into antigen specific immunotherapy for chronic myeloid leukemia.

Authors:  Yangqiu Li; Chen Lin; Christian A Schmidt
Journal:  Cancer Cell Int       Date:  2012-12-15       Impact factor: 5.722

10.  Alternative expression of TCRζ related genes in patients with chronic myeloid leukemia.

Authors:  Xianfeng Zha; Xiaojuan Yan; Qi Shen; Yuping Zhang; Xiuli Wu; Shaohua Chen; Bo Li; Lijian Yang; Suxia Geng; Jianyu Weng; Xin Du; Yangqiu Li
Journal:  J Hematol Oncol       Date:  2012-12-10       Impact factor: 17.388
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