S Y Kim1, J-H Lim, J-H Yang, M-Y Kim, M-H Kim, S-Y Park, H-M Ryu. 1. The Laboratory of Medical Genetics, Cheil General Hospital and Women's Healthcare Center, Kwandong University School of Medicine, Seoul, Korea.
Abstract
OBJECTIVE: Increased inhibin A serum and plasma levels in the second trimester are significantly associated with the development of preeclampsia. The measurement of inhibin A during early pregnancies may be helpful to predict those at risk of this disorder. The purpose of this study was to determine whether the 769G>A variant of the inhibin alpha (INHalpha) gene was associated with preeclampsia. PATIENTS AND METHODS: We screened the 769G>A variation in 162 preeclamptic patients and in 202 normal pregnancies. The 769G>A variant of the INHalpha gene was determined by the PCR-based restriction fragment length polymorphism analysis and DNA sequencing. RESULTS: We found no variation between the normal subjects and the preeclamptic patients. CONCLUSION: The 769G>A variant of the INHalpha gene may be rare in Korean patients with preeclampsia.
OBJECTIVE: Increased inhibin A serum and plasma levels in the second trimester are significantly associated with the development of preeclampsia. The measurement of inhibin A during early pregnancies may be helpful to predict those at risk of this disorder. The purpose of this study was to determine whether the 769G>A variant of the inhibin alpha (INHalpha) gene was associated with preeclampsia. PATIENTS AND METHODS: We screened the 769G>A variation in 162 preeclamptic patients and in 202 normal pregnancies. The 769G>A variant of the INHalpha gene was determined by the PCR-based restriction fragment length polymorphism analysis and DNA sequencing. RESULTS: We found no variation between the normal subjects and the preeclamptic patients. CONCLUSION: The 769G>A variant of the INHalpha gene may be rare in Korean patients with preeclampsia.
Authors: S Muttukrishna; R A North; J Morris; J C Schellenberg; R S Taylor; J Asselin; W Ledger; N Groome; C W Redman Journal: Hum Reprod Date: 2000-07 Impact factor: 6.918
Authors: A N Shelling; K A Burton; A L Chand; C C van Ee; J T France; C M Farquhar; S R Milsom; D R Love; K Gersak; K Aittomäki; I M Winship Journal: Hum Reprod Date: 2000-12 Impact factor: 6.918
Authors: P Ciarmela; P Florio; S Battistini; D Grasso; T Amato; S Boschi; L Marozio; C Benedetto; F Petraglia Journal: J Endocrinol Invest Date: 2005-01 Impact factor: 4.256