| Literature DB >> 18851963 |
Abstract
This review focuses on IRS-1 and the evidence of its role in cell transformation. The literature strongly suggests that IRS-1 should be considered a biomaker for cancers susceptible to IGF-IR targeting. In addition, I would like to propose that IRS-1 may have a more general role in cancer, and could be considered as a protein having the opposite effect of tumor suppressors, a sort of anti-p53 molecule.Entities:
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Year: 2008 PMID： 18851963 DOI： 10.1016/j.yexcr.2008.09.017
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905