Peter T Morgan1, Robert T Malison. 1. Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06519, USA. peter.morgan@yale.edu
Abstract
OBJECTIVES: To test the effects of mechanistically different GABA modulating agents on the disrupted sleep and cognitive function associated with abstinence from cocaine. METHODS: We examined the effects of lorazepam and tiagabine on polysomnographically measured sleep and cognition in six cocaine dependent persons. Participants were studied during the first and second week of controlled abstinence following intravenous, laboratory cocaine administration. RESULTS: Lorazepam and tiagabine decreased sleep latency, but whereas lorazepam markedly increased light sleep, tiagabine caused a dramatic shift toward slow-wave sleep. Despite increasing total sleep time, lorazepam impaired sleep dependent learning and increased next day impulsivity. CONCLUSIONS: These results introduce the possibility of different, sleep-related cognitive effects of mechanistically distinct GABAergic sedative hypnotics.
OBJECTIVES: To test the effects of mechanistically different GABA modulating agents on the disrupted sleep and cognitive function associated with abstinence from cocaine. METHODS: We examined the effects of lorazepam and tiagabine on polysomnographically measured sleep and cognition in six cocaine dependent persons. Participants were studied during the first and second week of controlled abstinence following intravenous, laboratory cocaine administration. RESULTS:Lorazepam and tiagabine decreased sleep latency, but whereas lorazepam markedly increased light sleep, tiagabine caused a dramatic shift toward slow-wave sleep. Despite increasing total sleep time, lorazepamimpaired sleep dependent learning and increased next day impulsivity. CONCLUSIONS: These results introduce the possibility of different, sleep-related cognitive effects of mechanistically distinct GABAergic sedative hypnotics.
Authors: D Matuskey; B Pittman; J I Chen; J Wanyiri; H Nadim; P Jatlow; R Gueorguieva; M N Potenza; P T Morgan; Z Bhagwagar; R T Malison Journal: Pharmacol Biochem Behav Date: 2012-11 Impact factor: 3.533
Authors: Gustavo A Angarita; Brian Pittman; Ralitza Gueorguieva; Rasmon Kalayasiri; Wendy J Lynch; Atapol Sughondhabirom; Peter T Morgan; Robert T Malison Journal: Pharmacol Biochem Behav Date: 2009-12-21 Impact factor: 3.533
Authors: Peter T Morgan; Edward Pace-Schott; Brian Pittman; Robert Stickgold; Robert T Malison Journal: Am J Psychiatry Date: 2010-01-15 Impact factor: 18.112
Authors: Peter T Morgan; Gustavo A Angarita; Sofija Canavan; Brian Pittman; Lindsay Oberleitner; Robert T Malison; Vahid Mohsenin; Sarah Hodges; Caroline Easton; Sherry McKee; Andrew Bessette; Erica Forselius Journal: Drug Alcohol Depend Date: 2016-01-08 Impact factor: 4.492