| Literature DB >> 18850478 |
Annelies M C Mavinkurve-Groothuis1, Livia Kapusta, Amiram Nir, Jacqueline Groot-Loonen.
Abstract
Anthracycline-induced cardiotoxicity can cause serious health problems for an increasing number of children surviving childhood malignancies. Early detection of cardiac failure is critically important for the prevention and management of anthracycline-induced cardiotoxicity. The aim of this research was to determine the role of biomarkers in the early detection of anthracycline-induced cardiotoxicity in children. A literature review is presented of studies regarding the use of the biomarkers B-type natriuretic peptide (BNP), N-terminal pro-BNP (NT-pro-BNP), cardiac troponin T (cTnT), and cardiac troponin I (cTnI) in relation with anthracycline-induced cardiotoxicity in children. Six of 14 studies in children showed a significant relation between elevated biomarkers BNP, NT-pro-BNP, and cTnT and cardiac dysfunction. Six studies, although small, suggest that BNP, NT-pro-BNP, and cTnT might be useful markers in the early detection of anthracycline-induced cardiotoxicity.Entities:
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Year: 2008 PMID： 18850478 DOI： 10.1080/08880010802244001
Source DB: PubMed Journal: Pediatr Hematol Oncol ISSN： 0888-0018 Impact factor: 1.969